ArticleJournal of molecular signaling2013
Neuronal aging: learning from C. elegans.
Article in Journal of molecular signaling, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- CYLD-mediated lysine63 deubiquitination regulates synaptic transmission and autophagy to mitigate age-related sequelae.Nature communications · 2026Article
- Unlocking neuronal health: leveraging C. elegans for drug repurposing studies.Cell communication and signaling : CCS · 2026Review
- Single-neuron analysis of aging-associated changes in learning reveals impairments in transcriptional plasticity.Aging cell · 2024Article
- The Axonal Actin Filament Cytoskeleton: Structure, Function, and Relevance to Injury and Degeneration.Molecular neurobiology · 2024Review
- High-throughput light sheet imaging of adult and larvalRSC advances · 2024Article
- Subcellular Imaging of Neuronal Calcium Handling In Vivo.Journal of visualized experiments : JoVE · 2023Article
- Cannabidiol: Bridge between Antioxidant Effect, Cellular Protection, and Cognitive and Physical Performance.Antioxidants (Basel, Switzerland) · 2023Review
- BAM15 Relieves Neurodegeneration in AgedMetabolites · 2022Article
- Cannabidiol induces autophagy and improves neuronal health associated with SIRT1 mediated longevity.GeroScience · 2022Article
- In vivo Assessment of Microtubule Dynamics and Orientation in Caenorhabditis elegans Neurons.Journal of visualized experiments : JoVE · 2021Article
- Structural aspects of the aging invertebrate brain.Cell and tissue research · 2021Review
- Flavonoids mitigate neurodegeneration in agedFood science & nutrition · 2020Article
- Tauopathy-associated tau modifications selectively impact neurodegeneration and mitophagy in a novel C. elegans single-copy transgenic model.Molecular neurodegeneration · 2020Article
- Review
- Isolation of Specific Neuron Populations from Roundworm Caenorhabditis elegans.Journal of visualized experiments : JoVE · 2019Article
- Review
- Bridging the gap: axonal fusion drives rapid functional recovery of the nervous system.Neural regeneration research · 2018Review
- Mitochondrial Uncoupling Attenuates Age-Dependent Neurodegeneration in C. elegans.Molecules and cells · 2017Article
- Uncoupling Protein, UCP-4 May Be Involved in Neuronal Defects During Aging and Resistance to Pathogens in Caenorhabditis elegans.Molecules and cells · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The heterogeneity and multigenetic nature of nervous system aging make modeling of it a formidable task in mammalian species. The powerful genetics, simple anatomy and short life span of the nematode Caenorhabditis elegans offer unique advantages in unraveling the molecular genetic network that regulates the integrity of neuronal structures and functions during aging. In this review, we first summarize recent breakthroughs in the morphological and functional characterization of C. elegans neuronal aging. Age-associated morphological changes include age-dependent neurite branching, axon beading or swelling, axon defasciculation, progressive distortion of the neuronal soma, and early decline in presynaptic release function. We then discuss genetic pathways that modulate the speed of neuronal aging concordant with alteration in life span, such as insulin signaling, as well as cell-autonomous factors that promote neuronal integrity during senescence, including membrane activity and JNK/MAPK signaling. As a robust genetic model for aging, insights from C. elegans neuronal aging studies will contribute to our mechanistic understanding of human brain aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.