ArticleThyroid : official journal of the American Thyroid Association2014
FOXE1 association with differentiated thyroid cancer and its progression.
Article in Thyroid : official journal of the American Thyroid Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 6 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 6 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Exploration of the association between FOXE1 gene polymorphism and differentiated thyroid cancer: a meta-analysis.BMC medical genetics · 2018Pooled it
- rs965513 polymorphism as a common risk marker is associated with papillary thyroid cancer.Oncotarget · 2016Pooled it
- TITF1 and TITF2 loci variants indicate significant associations with thyroid cancer.Endocrine · 2015Pooled it
- Replication and Meta-Analysis of Common Gene Mutations in TTF1 and TTF2 with Papillary Thyroid Cancer.Medicine · 2015Pooled it
- Common genetic variant on 14q13.3 contributes to thyroid cancer susceptibility: evidence based on 12 studies.Molecular genetics and genomics : MGG · 2015Pooled it
- Common genetic variants on FOXE1 contributes to thyroid cancer susceptibility: evidence based on 16 studies.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- The FOXE1 rs965513 polymorphism: a pleiotropic risk locus associated with thyroid function, BRAFScientific reports · 2026Article
- Forkhead box E1, frequently downregulted by promoter methylation, inhibits colorectal cancer cell growth and migration.Cancer cell international · 2024Article
- Identification of GermlineInternational journal of molecular sciences · 2024Article
- The high expression of FOXE1 in colorectal cancer predicts a promising prognosis: a retrospective study.Clinical and experimental medicine · 2023Article
- The Role of Genetic Polymorphisms in Differentiated Thyroid Cancer: A 2023 Update.Biomedicines · 2023Review
- Foxe1 Deletion in the Adult Mouse Is Associated With Increased Thyroidal Mast Cells and Hypothyroidism.Endocrinology · 2022Article
- Review
- Identifying Thyroid Carcinoma-Related Genes by Integrating GWAS and eQTL Data.Frontiers in cell and developmental biology · 2021Article
- Article
- The Contribution of Genetic Variants to the Risk of Papillary Thyroid Carcinoma in the Kazakh Population: Study of Common Single Nucleotide Polymorphisms and Their Clinicopathological Correlations.Frontiers in endocrinology · 2020Article
- Review
- A Case of Papillary Thyroid Carcinoma and Kostmann Syndrome: A Genomic Theranostic Approach for Comprehensive Treatment.The American journal of case reports · 2019Article
- Article
- The Dominant Role of Forkhead Box Proteins in Cancer.International journal of molecular sciences · 2018Review
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSingle nucleotide polymorphisms (SNPs) near thyroid transcription factor genes (FOXE1 rs965513/NKX2-1 rs944289) have been shown to be associated with differentiated thyroid cancer (DTC) in Caucasoid populations. We investigated the role of those SNPs in German patients with DTC and also extended our analysis to tumor stages and lymphocytic infiltration of the tumors (ITL).
methodsPatients with DTC (n=243; papillary, PTC; follicular, FTC) and healthy controls (HC; n=270) were analyzed for the rs965513 and rs944289 SNPs.
resultsThe case-control analysis for rs965513 SNP showed that the genotypes "AA," "AG," and minor allele "A" were more frequent in patients with DTC than in HC (pronounced in PTC p(genotype)=0.000084, p(allele)=0.006 than FTC p(genotype)=0.29 and p(allele)=0.06). Furthermore, subgroup analysis of the DTC patients stratified for primary tumor stage (T1-T2, T3-T4), the absence or presence of regional lymph node metastases (N0, N1), for distant metastases (M0, M1), as well as for ITL, showed an association of rs965513 with stages T1-T2, T1-T3, N1, and absence of ITL. The NKX2-1 SNP rs944289, however, was not associated with DTC.
conclusionOur results confirm that the FOXE1 rs965513 SNP confers an increased risk for DTC in the German population, particularly allele "A" and the genotypes "AA" and "AG" for PTC. This increased risk was also observed in advanced tumor stages and absence of ITL, which may reflect the course of a more aggressive disease. The NKX2-1 rs944289 SNP, however, appears to play a secondary role in the development of DTC in the German population.
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