Trial reportJournal of clinical hypertension (Greenwich, Conn.)2014
Visit-to-visit blood pressure variability and cardiovascular death in the Systolic Hypertension in the Elderly Program.
Trial report in Journal of clinical hypertension (Greenwich, Conn.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Blood pressure variability and cardiovascular disease: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2016Pooled it
- Visit-to-visit variability of blood pressure and cardiovascular disease and all-cause mortality: a systematic review and meta-analysis.Hypertension (Dallas, Tex. : 1979) · 2014Pooled it
- Visit-to-Visit Office Blood Pressure Variability and Cardiovascular Outcomes in SPRINT (Systolic Blood Pressure Intervention Trial).Hypertension (Dallas, Tex. : 1979) · 2017Trial
- Ambulatory 24-hour cardiac oxygen consumption and blood pressure-heart rate variability: effects of nebivolol and valsartan alone and in combination.Journal of the American Society of Hypertension : JASH · 2015Trial
- Visit-to-Visit Blood Pressure Variability as a Risk Factor for All-Cause Mortality, Cardiovascular Mortality, and Major Adverse Cardiovascular Events Among American Indians: the Strong Heart Study.Preventing chronic disease · 2025Article
- Article
- First-line diuretics versus other classes of antihypertensive drugs for hypertension.The Cochrane database of systematic reviews · 2023Review
- Therapeutic roles of thiazides and loop diuretics in blood pressure control and renal protection against chronic kidney disease.Clinical hypertension · 2023Review
- The relationship between day-to-day variability in home blood pressure measurement and multiple organ function.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Article
- Blood pressure visit-to-visit variability and outcomes in patients with heart failure with preserved ejection fraction.ESC heart failure · 2021Article
- Visit-to-visit variability of blood pressure and cardiovascular events among the working-age population in Japan: findings from the Japan Epidemiology Collaboration on Occupational Health Study.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Article
- Association of Blood Pressure Variability and Diuretics With Cardiovascular Events in Patients With Chronic Kidney Disease Stages 1-5.Hypertension (Dallas, Tex. : 1979) · 2021Article
- Single-pill combination of cilnidipine, an l-/n-type calcium channel blocker, and valsartan reduces the day-by-day variability of morning home systolic blood pressure in patients with treated hypertension: A sub-analysis of the HOPE-combi survey.Journal of clinical hypertension (Greenwich, Conn.) · 2021Observational
- Contributions to Hypertension Public Policy and Clinical Practice: A Review of Recent Reports.Journal of clinical hypertension (Greenwich, Conn.) · 2016Review
- Visit-to-Visit Variability of BP and CKD Outcomes: Results from the ALLHAT.Clinical journal of the American Society of Nephrology : CJASN · 2016Observational
- Review of New Statistical Techniques for Analysis of Cardiovascular Trial and Registry Data.Current hypertension reports · 2015Review
- Visit-to-Visit Variability of Systolic Blood Pressure and Cardiovascular Disease.Current hypertension reports · 2015Review
- Visit-to-visit blood pressure variability: more to come.Journal of clinical hypertension (Greenwich, Conn.) · 2015Article
- Understanding visit-to-visit blood pressure variability.Journal of clinical hypertension (Greenwich, Conn.) · 2014Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most studies of an association of visit-to-visit variability of blood pressure with increased risk of future adverse cardiovascular events are of short duration and rarely include a placebo group. Using data from the double-blind, placebo-controlled Systolic Hypertension in the Elderly Program, the authors examined mortality from cardiovascular causes up to 17 years of follow-up using the National Death Index. Visit-to-visit blood pressure variability was associated with cardiovascular death after adjustment for sex, age, serum creatinine, diabetes, body mass index, smoking status, left ventricular failure, and high-density lipoprotein cholesterol. The relationship was significantly stronger in the active treatment group compared with the placebo group. Although this could be the result of an effect of the medications used unrelated to visit-to-visit variability, the data are compatible with the hypothesis that inconsistent adherence leading to missing active medication doses may be an additional explanation for the relationship of visit-to-visit variability with cardiovascular death.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.