Evidence map›Paper›PMID 24325590›Full record

ArticleAlcoholism, clinical and experimental research2014

Commentary on the interactions of HIV and alcohol in the central nervous system.

Madhavan P Nair, Marisela Agudelo

Abstract readComment
In one paragraph

Article in Alcoholism, clinical and experimental research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Madhavan P NairDepartment of Immunology , Institute of NeuroImmune Pharmacology, Herbert Wertheim College of Medicine, AHC-I 418A, Florida International University, Miami, Florida.
Marisela Agudelo

Funding

Cocaine in the Neuropathogenesis of HIV infection: Role of HDAC2R01DA034547 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI NAIR, MADHAVAN P. · 2013 to 2018
$1.8M
EtOH-induced Immunomodulation: Role of Histone Deacetylases and Cannabinoid GenesK99AA021264 · NIAAA · FLORIDA INTERNATIONAL UNIVERSITY · PI AGUDELO, MARISELA · 2013 to 2014
$176k
NIAAA NIH HHS K99 AA021264NIDA NIH HHS R01 DA034547
6 · The paper itself

Abstract

This commentary is to highlight the relevance and public interest of the review published by Silverstein and Kumar, which focuses on the mechanisms by which alcohol and HIV-1 infection cause increased in central nervous system (CNS) damage. The overall review is based on previous literature with cell culture systems and animal models that have demonstrated that exposure to alcohol and HIV infection or HIV viral proteins result in synergistic up-regulation of pro-inflammatory cytokines and oxidative stress. The authors discuss the effects of alcohol on cells in the CNS, followed by a brief discussion on the impact of HIV-1 and HIV proteins on the CNS, and the final section focuses on the combined effects of HIV and alcohol on the CNS as determined by in vitro, in vivo, and clinical studies.

Indexed as

Host-Pathogen InteractionsAlcohol DrinkingAnimalsCentral Nervous SystemHIV-1HIV InfectionsHumansAlcoholCentral Nervous SystemHIV

Identifiers

PMID24325590
PMCPMC3959270

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.