ArticleBMC oral health2013
Erosive and cariogenicity potential of pediatric drugs: study of physicochemical parameters.
Article in BMC oral health, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 59 citations in OpenAlex.
- Multimodal Evaluation of Surface Topography and Color Stability in Pediatric Restorative Materials Exposed to Antihistamine Syrups.Journal of functional biomaterials · 2026Article
- Physicochemical evaluation of pediatric liquid medicines in Ghana: implications for cariogenicity and erosive potential.BMC oral health · 2026Article
- Dental service utilisation and perceptions amongst Indian rural children with intellectual and developmental disabilities.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Pediatric Liquid Medications and Dental Caries: A Narrative Review.Health science reports · 2025Article
- Effect of SucrosomialFrontiers in dentistry · 2022Article
- Dental caries in children and adolescents with juvenile idiopathic arthritis and controls: a multilevel analysis.BMC oral health · 2021Article
- Evaluation of the Erosive and Cariogenic Potential of Over-the-Counter Pediatric Liquid Analgesics and Antipyretics.Children (Basel, Switzerland) · 2021Article
- Relationship of pH and the viscosity of five different iron supplements with the absorption of iron ions and enamel discoloration in the anterior primary teeth (anDental research journal · 2021Article
- Drug-Induced Dental Caries: A Disproportionality Analysis Using Data from VigiBase.Drug safety · 2017Article
- Effects of Different Pediatric Drugs on the Color Stability of Various Restorative Materials Applicable in Pediatric Dentistry.BioMed research international · 2017Article
- Comparison of Dental Caries Experience in Children Suffering From Epilepsy with and without Administration of Long Term Liquid Oral Medication.Journal of clinical and diagnostic research : JCDR · 2016Article
- Effect of Zamzam Water on Microhardness of Primary Tooth Enamel After Erosion Induced by Claritin Syrup: AnJournal of International Society of Preventive & Community DentistryArticle
- Sweetener content and cariogenic potential of pediatric oral medications: A literature.International journal of health sciencesReview
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPediatric medications may possess a high erosive potential to dental tissues due to the existence of acid components in their formulations. The purpose was to determine the erosive and cariogenic potential of pediatric oral liquid medications through the analysis of their physicochemical properties in vitro.
methodsA total of 59 substances were selected from the drug reference list of the National Health Surveillance Agency (ANVISA), which belong to 11 therapeutic classes, as follows: analgesics, non-steroidal anti-inflammatory, corticosteroids, antihistamines, antitussives, bronchodilators, antibacterials, antiparasitics, antiemetics, anticonvulsants and antipsychotics. Measurement of pH was performed by potentiometry, using a digital pH meter. For the Total Titratable Acidity (TTA) chemical assay, a 0.1 N NaOH standard solution was used, which was titrated until drug pH was neutralized. The Total Soluble Solids Contents (TSSC) quantification was carried out by refractometry using Brix scale and the analysis of Total Sugar Content was performed according to Fehling's method. In addition, it was analyzed the information contained in the drug inserts with regard to the presence of sucrose and type of acid and sweetener added to the formulations.
resultsAll drug classes showed acidic pH, and the lowest mean was found for antipsychotics (2.61 ± 0.08). There was a large variation in the TTA (0.1% - 1.18%) and SST (10.44% - 57.08%) values. High total sugar contents were identified in the antitussives (53.25%) and anticonvulsants (51.75%). As described in the drug inserts, sucrose was added in 47.5% of the formulations, as well as citric acid (39.0%), sodium saccharin (36.4%) and sorbitol (34.8%).
conclusionThe drugs analyzed herein showed physicochemical characteristics indicative of a cariogenic and erosive potential on dental tissues. Competent bodies' strategies should be implemented in order to broaden the knowledge of health professionals, drug manufacturers and general consuming public about the risks from the consumption of medicines potentially harmful to dental tissues.
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