Evidence map›Paper›PMID 24325152›Full record

ReviewBritish journal of clinical pharmacology2015

Clinical trials in children.

Pathma D Joseph, Jonathan C Craig, Patrina H Y Caldwell

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in British journal of clinical pharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05936853 (The EPigenetic Consequences in Children of Intravenous vs Volatile Anaesthesia for Surgery), which is not on this map. Cited by 176 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
176citing papers in PubMed, 14 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05936853 naactive not recruitingnot on this mapstarted 2023, after this paper: background citation

The EPigenetic Consequences in Children of Intravenous vs Volatile Anaesthesia for Surgery (EPIVA) - A Randomised, Feasibility Trial

TypeinterventionalSponsorUniversity Hospital Southampton NHS Foundation TrustRan2023 to 2026Enrolled16ConditionsHypospadias, Anesthesia, Adverse Effect, Perioperative ComplicationArmsIntravenous approach to anaesthetic maintenance, Inhalational approach to anaesthetic maintenance
3 · Its place in the literature

Who cites it

176 citing papers in PubMed, 14 syntheses or guidelines pooled it.

  1. Pooled it
  2. Outcome measures in childhood glaucoma: a systematic review of randomized controlled trials.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023
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  9. Development of an evidence-based decision aid on complementary and alternative medicine (CAM) and pain for parents of children with cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
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  19. Journal of child health care : for professionals working with children in the hospital and community · 2022
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116 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Pathma D JosephThe Discipline of Paediatrics and Child Health, The Children's Hospital at Westmead, The University of Sydney, Westmead, NSW, Australia.
Jonathan C Craig
Patrina H Y Caldwell

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Safety and efficacy data on many medicines used in children are surprisingly scarce. As a result children are sometimes given ineffective medicines or medicines with unknown harmful side effects. Better and more relevant clinical trials in children are needed to increase our knowledge of the effects of medicines and to prevent the delayed or non-use of beneficial therapies. Clinical trials provide reliable evidence of treatment effects by rigorous controlled testing of interventions on human subjects. Paediatric trials are more challenging to conduct than trials in adults because of the paucity of funding, uniqueness of children and particular ethical concerns. Although current regulations and initiatives are improving the scope, quantity and quality of trials in children, there are still deficiencies that need to be addressed to accelerate radically equitable access to evidence-based therapies in children.

Indexed as

Clinical Trials as TopicPediatricsChildDrug EvaluationDrugs, InvestigationalEthics, MedicalHumansResearch DesignDrugs, Investigationalclinical trialsethicsmedicines in childrenpaediatric drug therapy

Identifiers

PMID24325152
PMCPMC4345947

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.