ArticleBioMed research international2013
Chitosan dermal substitute and chitosan skin substitute contribute to accelerated full-thickness wound healing in irradiated rats.
Article in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 46 citations in OpenAlex.
- The wound healing effects of linearly polarized irradiation in photobiomodulation.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025Article
- Advancements in bioengineered and autologous skin grafting techniques for skin reconstruction: a comprehensive review.Frontiers in bioengineering and biotechnology · 2024Article
- A novel hydrogel containing 4-methylcatechol for skin regeneration: in vitro and in vivo study.Biomedical engineering letters · 2023Article
- Local anti-inflammatory effect and immunomodulatory activity of chitosan-based dressing in skin wound healing: A systematic review.Journal of clinical and translational research · 2022Review
- Comparison of Glyaderm with different dermal substitute matrices in a porcine wound model.JPRAS open · 2022Article
- An Investigation of the Sol-Gel Transition of Chitosan Lactate and Chitosan Chloride Solutions via Rheological and NMR Studies.Gels (Basel, Switzerland) · 2022Article
- Selenium-Stimulated Exosomes Enhance Wound Healing by Modulating Inflammation and Angiogenesis.International journal of molecular sciences · 2022Article
- Hair Follicle Stem Cells for Tissue Regeneration.Tissue engineering. Part B, Reviews · 2022Review
- Cellular human tissue-engineered skin substitutes investigated for deep and difficult to heal injuries.NPJ Regenerative medicine · 2021Review
- β-Cyclodextrin/Triclosan Complex-Grafted Methacrylated Glycol Chitosan Hydorgel by Photocrosslinking via Visible Light Irradiation for a Tissue Bio-Adhesive.International journal of molecular sciences · 2021Article
- Review
- Skin tissue regeneration for burn injury.Stem cell research & therapy · 2019Review
- Biomaterials for Skin Substitutes.Advanced healthcare materials · 2018Review
- Bioactive polysaccharides from natural resources including Chinese medicinal herbs on tissue repair.Chinese medicine · 2018Review
- Far infrared promotes wound healing through activation of Notch1 signaling.Journal of molecular medicine (Berlin, Germany) · 2017Article
- Article
- Methodologies in creating skin substitutes.Cellular and molecular life sciences : CMLS · 2016Review
- Compatibility of Porous Chitosan Scaffold with the Attachment and Proliferation of human Adipose-Derived Stem CellsJournal of stem cells & regenerative medicine · 2016Article
- A Bilayer Engineered Skin Substitute for Wound Repair in an Irradiation-Impeded Healing Model on Rat.Advances in wound care · 2015Article
- Vital roles of stem cells and biomaterials in skin tissue engineering.World journal of stem cells · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wounds with full-thickness skin loss are commonly managed by skin grafting. In the absence of a graft, reepithelialization is imperfect and leads to increased scar formation. Biomaterials can alter wound healing so that it produces more regenerative tissue and fewer scars. This current study use the new chitosan based biomaterial in full-thickness wound with impaired healing on rat model. Wounds were evaluated after being treated with a chitosan dermal substitute, a chitosan skin substitute, or duoderm CGF. Wounds treated with the chitosan skin substitute showed the most re-epithelialization (33.2 ± 2.8%), longest epithelial tongue (1.62 ± 0.13 mm), and shortest migratory tongue distance (7.11 ± 0.25 mm). The scar size of wounds treated with the chitosan dermal substitute (0.13 ± 0.02 cm) and chitosan skin substitute (0.16 ± 0.05 cm) were significantly decreased (P < 0.05) compared with duoderm (0.45 ± 0.11 cm). Human leukocyte antigen (HLA) expression on days 7, 14, and 21 revealed the presence of human hair follicle stem cells and fibroblasts that were incorporated into and surviving in the irradiated wound. We have proven that a chitosan dermal substitute and chitosan skin substitute are suitable for wound healing in full-thickness wounds that are impaired due to radiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.