ArticleBioMed research international2013
Teratogenic potential of antiepileptic drugs in the zebrafish model.
Article in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- A Systematic Review to Compare Chemical Hazard Predictions of the Zebrafish Embryotoxicity Test With Mammalian Prenatal Developmental Toxicity.Toxicological sciences : an official journal of the Society of Toxicology · 2021Pooled it
- Novel polyvinyl alcohol-borax hydrogel with potential to accelerate skin wound healing in aquatic models: zebrafish and tilapia.Royal Society open science · 2026Article
- Lacosamide Is a Novel Drug That Improves AGTPBP1 Knockout-Mediated Impairment of Neuronal and Dopaminergic Function.Molecular neurobiology · 2025Article
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- The Safety of Alcohol Pharmacotherapies in Pregnancy: A Scoping Review of Human and Animal Research.CNS drugs · 2025Article
- The herbicide acetochlor causes lipid peroxidation by inhibition of glutathione peroxidase activity.Toxicological sciences : an official journal of the Society of Toxicology · 2024Article
- Assessing developmental toxicity and non-CYP mediated biotransformation of two anti-epileptics and their human metabolites in zebrafish embryos and larvae.Current research in toxicology · 2024Article
- Article
- Developmental Neurotoxicity of Environmentally Relevant Pharmaceuticals and Mixtures Thereof in a Zebrafish Embryo Behavioural Test.International journal of environmental research and public health · 2021Article
- Neurotoxic effects in zebrafish embryos by valproic acid and nine of its analogues: the fish-mouse connection?Archives of toxicology · 2021Article
- DMSO Concentrations up to 1% are Safe to be Used in the Zebrafish Embryo Developmental Toxicity Assay.Frontiers in toxicology · 2021Article
- Toxicological Parameters of a Formulation Containing Cinnamaldehyde for Use in Treatment of Oral Fungal Infections: AnBioMed research international · 2021Article
- Lacosamide intake during pregnancy increases the incidence of foetal malformations and symptoms associated with schizophrenia in the offspring of mice.Scientific reports · 2020Article
- Use of Zebrafish in Drug Discovery Toxicology.Chemical research in toxicology · 2020Review
- Effects of lacosamide "a novel antiepileptic drug" in the early stages of chicken embryo development.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The zebrafish model is an attractive candidate for screening of developmental toxicity during early drug development. Antiepileptic drugs (AEDs) arouse concern for the risk of teratogenicity, but the data are limited. In this study, we evaluated the teratogenic potential of seven AEDs (carbamazepine (CBZ), ethosuximide (ETX), valproic acid (VPN), lamotrigine (LMT), lacosamide (LCM), levetiracetam (LVT), and topiramate (TPM)) in the zebrafish model. Zebrafish embryos were exposed to AEDs from initiation of gastrula (5.25 hours post-fertilization (hpf)) to termination of hatching (72 hpf) which mimic the mammalian teratogenic experimental design. The lethality and teratogenic index (TI) of AEDs were determined and the TI values of each drug were compared with the US FDA human pregnancy categories. Zebrafish model was useful screening model for teratogenic potential of antiepilepsy drugs and was in concordance with in vivo mammalian data and human clinical data.
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