ArticlePloS one2013
Trends in antibiotic treatment of acute otitis media and treatment failure in children, 2000-2011.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Impact of acute otitis media clinical practice guidelines on antibiotic and analgesic prescriptions: a systematic review.Archives of disease in childhood · 2018Pooled it
- Interventions to Minimize Unnecessary Antibiotic Use for Acute Otitis Media: A Meta-Analysis.Children (Basel, Switzerland) · 2025Review
- Exploring the Potential of Bee-Derived Antioxidants for Maintaining Oral Hygiene and Dental Health: A Comprehensive Review.Antioxidants (Basel, Switzerland) · 2023Review
- Impact of pneumococcal conjugate vaccines on healthcare utilization and direct costs for otitis media in children ≤2 years of age in two Swedish regions.Human vaccines & immunotherapeutics · 2022Article
- The effect of pneumococcal conjugate vaccines on otitis media from 2005 to 2013 in children aged ≤5 years: a retrospective cohort study in two Swedish regions.Human vaccines & immunotherapeutics · 2021Article
- Economic Evaluation of FebriDx®: A Novel Rapid, Point-of-Care Test for Differentiation of Viral versus Bacterial Acute Respiratory Infection in the United States.Journal of health economics and outcomes research · 2021Article
- Leukotriene B4 Is a Major Determinant of Leukocyte Recruitment During Otitis Media.Frontiers in cellular and infection microbiology · 2021Article
- Penicillin Allergy Delabeling: A Multidisciplinary Opportunity.The journal of allergy and clinical immunology. In practice · 2020Review
- Children with reported penicillin allergy: Public health impact and safety of delabeling.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2020Review
- Oral prednisolone for acute otitis media in children: a pilot, pragmatic, randomised, open-label, controlled study (OPAL study).Pilot and feasibility studies · 2020Article
- Antibiotic exposure and 'response failure' for subsequent respiratory tract infections: an observational cohort study of UK preschool children in primary care.The British journal of general practice : the journal of the Royal College of General Practitioners · 2019Observational
- Pain management in acute otitis media: a qualitative study of parents' views and expectations.BMC family practice · 2019Article
- Automated classification platform for the identification of otitis media using optical coherence tomography.NPJ digital medicine · 2019Article
- Differences in Antibiotic Resistance of MRSA Infections in Patients with Various Types of Otitis Media.The journal of international advanced otology · 2018Article
- Trends in healthcare utilization and costs associated with acute otitis media in the United States during 2008-2014.BMC health services research · 2018Article
- Otitis Media in Fully Vaccinated Preschool Children in the Pneumococcal Conjugate Vaccine Era.Global pediatric health · 2017Article
- Multi-scale finite element modeling of Eustachian tube function: influence of mucosal adhesion.International journal for numerical methods in biomedical engineering · 2016Article
- Using the shortwave infrared to image middle ear pathologies.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Interpretation of tympanic membrane findings varies according to level of experience.Paediatrics & child health · 2016Article
- Otitis Media and Related Complications Among Children with Autism Spectrum Disorders.Journal of autism and developmental disorders · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectivesGuidelines to treat acute otitis media (AOM) were published in 2004. Initial declines in prescribing were shown, but it's unknown if they were sustained. We examine trends in antibiotic dispensing patterns to treat AOM among a large population of children. We also document trends in antibiotic failure. STUDY
designChildren aged 3 months to 12 years with an AOM diagnosis, enrolled in a commercial claims database between January 1, 2000-December 31, 2011 were included. Pharmacy claims within 7 days of diagnosis were searched for antibiotic prescriptions. Antibiotic failure was defined as a dispensing of a different antibiotic class within 2-18 days after the first prescription. We analyzed trends in antibiotic use and failure by class of antibiotic and year.
resultsWe identified over 4 million children under 13 years with AOM. The proportion of antibiotic dispensing decreased from 66.0% in 2005 to 51.9% in 2007, after which the instances of dispensing rebounded to pre-guideline levels. However, levels began decreasing again in 2010 and the antibiotic use rate in 2011 was 57.6%. Cephalosporin prescriptions increased by 41.5% over eleven years. Antibiotic failure decreased slightly, and macrolides had the lowest proportion of failures, while all other classes had failure rates around 10%.
conclusionsIn recent years, antibiotic dispensing to treat AOM remains high. In addition, the use of broad-spectrum antibiotics is increasing despite having a high rate of treatment failure. Overprescribing of antibiotics and use of non-penicillin therapy for AOM treatment could lead to the development of antibiotic-resistant infections.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.