SynthesisPloS one2013
The tip of the "celiac iceberg" in China: a systematic review and meta-analysis.
Synthesis in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Meta-Analysis and Systematic Review of HLA DQ2/DQ8 in Adults with Celiac Disease.International journal of molecular sciences · 2023Pooled it
- HLA-DQ genetics in children with celiac disease: a meta-analysis suggesting a two-step genetic screening procedure starting with HLA-DQ β chains.Pediatric research · 2018Pooled it
- Prevalence of Celiac Disease in China Among High-Risk Populations: A Systematic Review and Meta-Analysis.Journal of digestive diseasesPooled it
- Letter to the editor regarding 'the plasma metabolome and clinical features of patients with coeliac disease in Northwest China'.Annals of medicine · 2026Article
- The plasma metabolome and clinical features of patients with coeliac disease in Northwest China.Annals of medicine · 2026Article
- Vitamin and trace elements imbalance are very common in adult patients with newly diagnosed Celiac disease.Scientific reports · 2025Article
- Advances in understanding and managing celiac disease: Pathophysiology and treatment strategies.World journal of gastroenterology · 2024Article
- Celiac Disease Genetics, Pathogenesis, and Standard Therapy for Japanese Patients.International journal of molecular sciences · 2023Review
- Epidemiological, clinical, and histological presentation of celiac disease in Northwest China.World journal of gastroenterology · 2022Article
- Celiac Disease Revisited.GE Portuguese journal of gastroenterology · 2022Review
- Celiac disease may be rare among children in South China.The Journal of international medical research · 2022Article
- Characteristics of gut microbiota and fecal metabolomes in patients with celiac disease in Northwest China.Frontiers in microbiology · 2022Article
- Circulating circular RNA profiles associated with celiac disease seropositivity in children with type 1 diabetes.Frontiers in pediatrics · 2022Article
- The surprising 'Coeliac Chinese box' from Italy.Gastroenterology report · 2021Article
- Emergence of Celiac disease and Gluten-related disorders in Asia.Journal of neurogastroenterology and motility · 2021Review
- Celiac Disease in Asia beyond the Middle East and Indian subcontinent: Epidemiological burden and diagnostic barriers.World journal of gastroenterology · 2021Article
- Evaluation of malnutrition status and clinical indications in children with celiac disease: a cross-sectional study.BMC pediatrics · 2021Article
- Opportunities and challenges in the management of celiac disease in Asia.JGH open : an open access journal of gastroenterology and hepatology · 2020Review
- Serological screening for celiac disease in adults in Japan: Shimane CoHRE study.JGH open : an open access journal of gastroenterology and hepatology · 2020Article
- Association of long noncoding RNA H19 polymorphisms with the susceptibility and clinical features of ischemic stroke in southern Chinese Han population.Metabolic brain disease · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveUntil recently, celiac disease was considered to be rare in China. We aimed to estimate its true status.
methodsBy searching the MEDLINE database and four Chinese full-text databases (CNKI, CBM, VIP and WANFANG) (up to August 2012), as well as two HLA allele frequency net databases and the Chinese Statistics Yearbook databases, we systematically reviewed the literature on definite and suspected cases of celiac disease, the predisposing HLA allele frequencies, and on gluten exposure in China. Meta-analysis was performed by analyzing DQ2, DQ8 and DQB1*0201 gene frequencies and heterogeneity in populations from different geographic regions and ethnicities in China.
resultsAt present, the number of reported celiac disease cases is extremely low in China. The frequencies of the HLA-DQ2.5 and HLA-DQ8 haplotypes were 3.4% (95% confidence interval 1.3-5.5%) and 2.1% (0.1-4.1%), respectively. HLA-DQ2 and HLA-DQ8 antigen frequencies were 18.4% (15.0-21.7%) and 8.0% (4.5-11.4%), respectively. The frequency of the DQB1*0201 allele was 10.5% (9.3-11.6%) and it was more common in the northern Chinese than in the southern Chinese populations. The chance of being exposed to gluten is rapidly increasing all over China nowadays.
conclusionThe data on HLA haplotyping, in conjunction with increasing wheat consumption, strongly suggests that the occurrence of celiac disease is more common in China than currently reported. Coordinated measures by the Chinese government, medical and agricultural research institutions, and food industries, would be justified to create more awareness about celiac disease and to prevent it becoming a medical and societal burden.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.