ArticlePloS one2013
Genome-wide association study for levels of total serum IgE identifies HLA-C in a Japanese population.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Transcriptome-wide association study of circulating IgE levels identifies novel targets for asthma and allergic diseases.Frontiers in immunology · 2023Pooled it
- Genetic predisposition to elevated total immunoglobulin E levels defines a distinct adult-onset-predominant asthma phenotype.Scientific reports · 2026Article
- Examining genotype-phenotype associations of GRAM domain proteins using GWAS, PheWAS and literature review in cattle, human, pig, mouse and chicken.Scientific reports · 2024Article
- The primary ciliary dyskinesia-related genetic risk score is associated with susceptibility to adult-onset asthma.PloS one · 2024Article
- Genome-wide identification of dysregulated alternative splicing and RNA-binding proteins involved in atopic dermatitis.Frontiers in genetics · 2024Article
- Article
- A Whole-Genome Sequencing Study Implicates GRAMD1B in Multiple Sclerosis Susceptibility.Genes · 2022Article
- Common exacerbation-prone phenotypes across asthma and chronic obstructive pulmonary disease (COPD).PloS one · 2022Article
- Expression quantitative trait loci for ETV4 and MEOX1 are associated with adult asthma in Japanese populations.Scientific reports · 2021Article
- Contribution of Antigen-Processing Machinery Genetic Polymorphisms to Atopic Dermatitis.Life (Basel, Switzerland) · 2021Article
- Association of the Promoter Haplotype of IFN-γ-Inducible Protein 16 Gene with Schizophrenia in a Korean Population.Psychiatry investigation · 2020Article
- High-Yield Production of the Major Birch Pollen Allergen Bet v 1 With Allergen Immunogenicity inFrontiers in plant science · 2020Article
- A cis-eQTL allele regulating reduced expression of CHI3L1 is associated with late-onset adult asthma in Japanese cohorts.BMC medical genetics · 2019Article
- Lessons Learned From GWAS of Asthma.Allergy, asthma & immunology research · 2019Review
- Low expression of a DGenes and immunity · 2019Article
- A decade of research on the 17q12-21 asthma locus: Piecing together the puzzle.The Journal of allergy and clinical immunology · 2018Review
- Rhinovirus infection induces distinct transcriptome profiles in polarized human macrophages.Physiological genomics · 2018Article
- An epigenome-wide association study of total serum IgE in Hispanic children.The Journal of allergy and clinical immunology · 2017Article
- Humoral immune factors and asthma among American Indian children: a case-control study.BMC pulmonary medicine · 2016Article
- Genome-wide association study of recalcitrant atopic dermatitis in Korean children.The Journal of allergy and clinical immunology · 2015Article
Corrections and comments
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Authors and funding
16 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most of the previously reported loci for total immunoglobulin E (IgE) levels are related to Th2 cell-dependent pathways. We undertook a genome-wide association study (GWAS) to identify genetic loci responsible for IgE regulation. A total of 479,940 single nucleotide polymorphisms (SNPs) were tested for association with total serum IgE levels in 1180 Japanese adults. Fine-mapping with SNP imputation demonstrated 6 candidate regions: the PYHIN1/IFI16, MHC classes I and II, LEMD2, GRAMD1B, and chr13∶60576338 regions. Replication of these candidate loci in each region was assessed in 2 independent Japanese cohorts (n = 1110 and 1364, respectively). SNP rs3130941 in the HLA-C region was consistently associated with total IgE levels in 3 independent populations, and the meta-analysis yielded genome-wide significance (P = 1.07×10(-10)). Using our GWAS results, we also assessed the reproducibility of previously reported gene associations with total IgE levels. Nine of 32 candidate genes identified by a literature search were associated with total IgE levels after correction for multiple testing. Our findings demonstrate that SNPs in the HLA-C region are strongly associated with total serum IgE levels in the Japanese population and that some of the previously reported genetic associations are replicated across ethnic groups.
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