ArticlePloS one2013
Seroprevalence of human enterovirus 71 and coxsackievirus A16 in Guangdong, China, in pre- and post-2010 HFMD epidemic period.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Seroprevalence of coxsackievirus A6 and enterovirus A71 infection in humans: a systematic review and meta-analysis.Archives of virology · 2023Pooled it
- The Epidemiology of Hand, Foot and Mouth Disease in Asia: A Systematic Review and Analysis.The Pediatric infectious disease journal · 2016Pooled it
- Seroprevalence of Enterovirus 71 Antibody Among Children in China: A Systematic Review and Meta-analysis.The Pediatric infectious disease journal · 2015Pooled it
- Enterovirus 71 seropositivity among children and adolescents in Bangladesh.IJID regions · 2025Article
- Article
- Seroprevalence of human enterovirus A71 in Guangzhou, China, 2019-2021.Biosafety and health · 2023Article
- Effect of difference between EV-A71 virus epidemic strain and "vaccine strain" on neutralizing antibody titer.Human vaccines & immunotherapeutics · 2022Article
- Seroprevalence of coxsackievirus A16 antibody among people of various age groups: a systematic review and meta-analysis.Archives of public health = Archives belges de sante publique · 2021Review
- Molecular surveillance of coxsackievirus A16 in southern China, 2008-2019.Archives of virology · 2021Article
- Tracking echovirus eleven outbreaks in Guangdong, China: a metatranscriptomic, phylogenetic, and epidemiological study.Virus evolution · 2020Article
- Process optimization for the rapid production of Enterovirus 71.Cytotechnology · 2019Article
- Seroprevalence of antibodies to enterovirus 71 and coxsackievirus A16 among people of various age groups in a northeast province of Thailand.Virology journal · 2018Article
- Severity and burden of hand, foot and mouth disease in Asia: a modelling study.BMJ global health · 2018Article
- Enterovirus 71 Neutralizing Antibodies Seroepidemiological Research among Children in Guangzhou, China between 2014 and 2015: A Cross-Sectional Study.International journal of environmental research and public health · 2017Article
- Prediction of Protection against Asian Enterovirus 71 Outbreak Strains by Cross-neutralizing Capacity of Serum from Dutch Donors, The Netherlands.Emerging infectious diseases · 2016Article
- Changes in enterovirus serotype constituent ratios altered the clinical features of infected children in Guangdong Province, China, from 2010 to 2013.BMC infectious diseases · 2016Article
- Serological detection and analysis of anti-VP1 responses against various enteroviruses (EV) (EV-A, EV-B and EV-C) in Chinese individuals.Scientific reports · 2016Article
- Seroepidemiology of Human Enterovirus 71 Infection among Children, Cambodia.Emerging infectious diseases · 2016Article
- Seroprevalence of Enterovirus A71 and Coxsackievirus A16 in Healthy People in Shandong Province, China.PloS one · 2016Article
- EV71 infection correlates with viral IgG preexisting at pharyngo-laryngeal mucosa in children.Virologica Sinica · 2015Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHuman Enterovirus 71 and Coxsackie A16 have caused many outbreaks in the last decade in mainland China, resulting in thousands of fatal cases. Seroepidemiology which provides important information to document population immunity is rare in China. METHODOLOGY/PRINCIPAL
findingsA cross sectional study of Enterovirus 71 (EV71) and Coxsackie A16 (CA16) seroprevalence was carried out in Guangdong, China, pre- and post- the 2010 hand, foot and mouth disease (HFMD) epidemic period. The levels of EV71 and CA16 specific antibodies were evaluated by a microneutralization test and the geometric mean titer (GMT) was calculated and compared. Our results indicated frequent infection by EV71 and CA16 in Guangdong before the 2010 epidemic. Only EV71 neutralizing antibody but not CA16 seroprevalence was significantly increased after the 2010 HFMD epidemic. Children less than 3 years old especially those aged 2 years showed the lowest positive rates for EV71 and CA16 NA before epidemic and the most significantly increased EV71 seroprevalence after epidemic. CA16 GMT values declined after the 2010 epidemic.
conclusionsThese results indicate EV71 was the major pathogen of HFMD in Guangdong during the 2010 epidemic. The infection occurs largely in children less than 3 years, who should have first priority to receive an EV71 vaccine.
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