ArticleInternational journal of endocrinology2013
Effect of gelam honey on the oxidative stress-induced signaling pathways in pancreatic hamster cells.
Article in International journal of endocrinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Honey and cancer: from traditional medicine to modern adjuvant therapy.Frontiers in oncology · 2026Review
- The protective effect of Saudi Arabian bee honey against excessive weight gain and obesity-related parameters in rats fed a high-fat diet.Frontiers in nutrition · 2025Article
- Understanding the Anticancer Properties of Honey.International journal of molecular sciences · 2024Review
- Hyperglycemia-induced oxidative stress and epigenetic regulation of ET-1 gene in endothelial cells.Frontiers in genetics · 2023Article
- The Mechanism of Honey in Reversing Metabolic Syndrome.Molecules (Basel, Switzerland) · 2021Review
- Physicochemical and Medicinal Properties of Tualang, Gelam and Kelulut Honeys: A Comprehensive Review.Nutrients · 2021Review
- Dahuang Danshen Decoction Inhibits Pancreatic Fibrosis by Regulating Oxidative Stress and Endoplasmic Reticulum Stress.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Prospects of honey in fighting against COVID-19: pharmacological insights and therapeutic promises.Heliyon · 2020Review
- Ameliorative Effects of Honey, Propolis, Pollen, and Royal Jelly Mixture against Chronic Toxicity of Sumithion Insecticide in White Albino Rats.Molecules (Basel, Switzerland) · 2020Article
- Honey reduces the metastatic characteristics of prostate cancer cell lines by promoting a loss of adhesion.PeerJ · 2018Article
- Honey as a Potential Natural Antioxidant Medicine: An Insight into Its Molecular Mechanisms of Action.Oxidative medicine and cellular longevity · 2018Review
- Stimulation of β-adrenergic receptors plays a protective role via increased expression of RAF-1 and PDX-1 in hyperglycemic rat pancreatic islet (RIN-m5F) cells.Archives of medical science : AMS · 2017Article
- Honey and Cancer: Current Status and Future Directions.Diseases (Basel, Switzerland) · 2016Review
- Withaferin A protects against palmitic acid-induced endothelial insulin resistance and dysfunction through suppression of oxidative stress and inflammation.Scientific reports · 2016Article
- Gelam Honey Attenuates the Oxidative Stress-Induced Inflammatory Pathways in Pancreatic Hamster Cells.Evidence-based complementary and alternative medicine : eCAM · 2016Article
- Insulin resistance provides the connection between hepatitis C virus and diabetes.Hepatitis monthly · 2015Article
- Effects of honey and its mechanisms of action on the development and progression of cancer.Molecules (Basel, Switzerland) · 2014Review
- ω-3 PUFA rich camelina oil by-products improve the systemic metabolism and spleen cell functions in fattening pigs.PloS one · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background. Oxidative stress induced by reactive oxygen and nitrogen species is critically involved in the impairment of β -cell function during the development of diabetes. Methods. HIT-T15 cells were cultured in 5% CO2 and then preincubated with Gelam honey extracts (20, 40, 60, and 80 µg/mL) as well as quercetin (20, 40, 60, and 80 µM), prior to stimulation by 20 and 50 mM of glucose. Cell lysate was collected to determine the effect of honey extracts and quercetin on the stress activated NF- κ B, MAPK pathways, and the Akt (ser473) activated insulin signaling pathway. Results. HIT-T15 cells cultured under hyperglycemic conditions demonstrated insulin resistance with a significant increase in the levels of MAPK, NF- κ B, and IRS-1 serine phosphorylation (ser307); however, Akt expression and insulin contents are significantly decreased. Pretreatment with quercetin and Gelam honey extract improved insulin resistance and insulin content by reducing the expression of MAPK, NF- κ B, and IRS-1 serine phosphorylation (ser307) and increasing the expression of Akt significantly. Conclusion. Gelam honey-induced differential expression of MAPK, NF- κ B, IRS-1 (ser307), and Akt in HIT-T15 cells shows that Gelam honey exerts protective effects against diabetes- and hyperglycemia-induced oxidative stress by improving insulin content and insulin resistance.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.