ArticleFrontiers in biology2012
NFκB signaling regulates embryonic and adult neurogenesis.
Article in Frontiers in biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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Who cites it
40 citing papers in PubMed, 60 citations in OpenAlex.
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- Apoptosis-dependent head development during metamorphosis of the cnidarian Hydractinia symbiolongicarpus.Developmental biology · 2024Article
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- Changes in the Proliferation of the Neural Progenitor Cells of Adult Mice Chronically Infected withMicroorganisms · 2023Article
- Alterations of microRNAs expression profiles in small extracellular vesicle after traumatic brain injury in mice.Experimental animals · 2022Article
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- It takes two to tango: Widening our understanding of the onset of schizophrenia from a neuro-angiogenic perspective.Frontiers in cell and developmental biology · 2022Review
- Sequence Variant in the TRIM39-RPP21 Gene Readthrough is Shared Across a Cohort of Arabian Foals Diagnosed with Juvenile Idiopathic Epilepsy.Journal of genetic mutation disorders · 2022Article
- A schizophrenia subgroup with elevated inflammation displays reduced microglia, increased peripheral immune cell and altered neurogenesis marker gene expression in the subependymal zone.Translational psychiatry · 2021Article
- Sex-Dependent Changes of miRNA Levels in the Hippocampus of Adrenalectomized Rats Following Acute Corticosterone Administration.ACS chemical neuroscience · 2021Article
- Association between genes regulating neural pathways for quantitative traits of speech and language disorders.NPJ genomic medicine · 2021Article
- Altered hypothalamic DNA methylation and stress-induced hyperactivity following early life stress.Epigenetics & chromatin · 2021Article
- Oxidative stress sensing and response in neural stem cell fate.Free radical biology & medicine · 2021Article
- Autism Spectrum Disorder: Signaling Pathways and Prospective Therapeutic Targets.Cellular and molecular neurobiology · 2021Review
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Both embryonic and adult neurogenesis involves the self-renewal/proliferation, survival, migration and lineage differentiation of neural stem/progenitor cells. Such dynamic process is tightly regulated by intrinsic and extrinsic factors and complex signaling pathways. Misregulated neurogenesis contributes much to a large range of neurodevelopmental defects and neurodegenerative diseases. The signaling of NFκB regulates many genes important in inflammation, immunity, cell survival and neural plasticity. During neurogenesis, NFκB signaling mediates the effect of numerous niche factors such as cytokines, chemokines, growth factors, extracellular matrix molecules, but also crosstalks with other signaling pathways such as Notch, Shh, Wnt/β-catenin. This review summarizes current progress on the NFκB signaling in all aspects of neurogenesis, focusing on the novel role of NFκB signaling in initiating early neural differentiation of neural stem cells and embryonic stem cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.