ArticleFrontiers in endocrinology2013
Thyroid Hormone Upregulates Hypothalamic kiss2 Gene in the Male Nile Tilapia, Oreochromis niloticus.
Article in Frontiers in endocrinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 52 citations in OpenAlex.
- Variations among Nile tilapia reproductive strains: An integrative morphometric and molecular approach.Journal of fish biology · 2026Article
- Longitudinal Evaluation of Reproductive Endocrine Function in Men With ACTH-Dependent Cushing Syndrome.The Journal of clinical endocrinology and metabolism · 2025Article
- The Thyroid Hormone Axis and Female Reproduction.International journal of molecular sciences · 2023Review
- Tsh Induces Agrp1 Neuron Proliferation in Oatp1c1-Deficient Zebrafish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Sexually dimorphic distribution of kiss1 and kiss2 in the brain of yellowtail clownfish, Amphiprion clarkii.Endocrine connections · 2022Article
- A New Perspective on Thyroid Hormones: Crosstalk with Reproductive Hormones in Females.International journal of molecular sciences · 2022Review
- Overview and New Insights Into the Diversity, Evolution, Role, and Regulation of Kisspeptins and Their Receptors in Teleost Fish.Frontiers in endocrinology · 2022Review
- New Evidence for the Existence of Two Kiss/Kissr Systems in a Flatfish Species, the Turbot (Frontiers in endocrinology · 2022Article
- Effects of Kiss2 on the Expression of Gonadotropin Genes in the Pituitary of Nile Tilapia (Development & reproduction · 2020Article
- Single-Cell Gene Profiling Reveals Social Status-Dependent Modulation of Nuclear Hormone Receptors in GnRH Neurons in a Male Cichlid Fish.International journal of molecular sciences · 2020Article
- The mRNA expression patterns of kisspeptins, GnRHs, and gonadotropins in the brain and pituitary gland of a tropical damselfish, Chrysiptera cyanea, during the reproductive cycle.Fish physiology and biochemistry · 2020Article
- Morphological Evidence for Functional Crosstalk Between Multiple GnRH Systems in the Male Tilapia,Frontiers in endocrinology · 2020Article
- Article
- Deciphering Direct and Indirect Effects of Neurokinin B and GnRH in the Brain-Pituitary Axis of Tilapia.Frontiers in endocrinology · 2019Article
- Tanycytes and the Control of Thyrotropin-Releasing Hormone Flux Into Portal Capillaries.Frontiers in endocrinology · 2019Review
- The Roles of Kisspeptin System in the Reproductive Physiology of Fish With Special Reference to Chub Mackerel Studies as Main Axis.Frontiers in endocrinology · 2018Review
- Biological Significance of Kisspeptin-Kiss 1 Receptor Signaling in the Habenula of Teleost Species.Frontiers in endocrinology · 2018Review
- Editorial: "Thyroid Hormone in Brain and Brain Cells".Frontiers in endocrinology · 2015Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Kisspeptin has recently been recognized as a critical regulator of reproductive function in vertebrates. During the sexual development, kisspeptin neurons receive sex steroids feedback to trigger gonadotropin-releasing hormone (GnRH) neurons. In teleosts, a positive correlation has been found between the thyroid status and the reproductive status. However, the role of thyroid hormone in the regulation of kisspeptin system remains unknown. We cloned and characterized a gene encoding kisspeptin (kiss2) in a cichlid fish, the Nile tilapia (Oreochromis niloticus). Expression of kiss2 mRNA in the brain was analyzed by in situ hybridization. The effect of thyroid hormone (triiodothyronine, T3) and hypothyroidism with methimazole (MMI) on kiss2 and the three GnRH types (gnrh1, gnrh2, and gnrh3) mRNA expression was analyzed by real-time PCR. Expression of thyroid hormone receptor mRNAs were analyzed in laser-captured kisspeptin and GnRH neurons by RT-PCR. The kiss2 mRNA expressing cells were seen in the nucleus of the lateral recess in the hypothalamus. Intraperitoneal administration of T3 (5 μg/g body weight) to sexually mature male tilapia significantly increased kiss2 and gnrh1 mRNA levels at 24 h post injection (P < 0.001), while the treatment with an anti-thyroid, MMI (100 ppm for 6 days) significantly reduced kiss2 and gnrh1 mRNA levels (P < 0.05). gnrh2, gnrh3, and thyrotropin-releasing hormone mRNA levels were insensitive to the thyroid hormone manipulations. Furthermore, RT-PCR showed expression of thyroid hormone receptor mRNAs in laser-captured GnRH neurons but not in kiss2 neurons. This study shows that GnRH1 may be directly regulated through thyroid hormone, while the regulation of Kiss2 by T3 is more likely to be indirect.
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