ReviewFrontiers in physiology2013
pH sensing via bicarbonate-regulated "soluble" adenylyl cyclase (sAC).
Review in Frontiers in physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 50 citations in OpenAlex.
- Soluble adenylyl cyclase in nonmammalian sperm is directly controlled by pH, not by HCOProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Combining dopamine and vitamin E enhances the differentiation to cholinergic neurons of mesenchymal stem cells.Journal of neuropathology and experimental neurology · 2025Article
- The synthetic cannabinoids menace: a review of health risks and toxicity.European journal of medical research · 2024Review
- Phosphorylation, compartmentalization, and cardiac function.IUBMB life · 2023Article
- Metabolic Dysregulation and Sperm Motility in Male Infertility.Advances in experimental medicine and biology · 2022Review
- Article
- Cyclic adenosine monophosphate (cAMP) signaling in melanocyte pigmentation and melanomagenesis.Pigment cell & melanoma research · 2021Review
- Cyclic AMP: A Polyhedral Signalling Molecule in Plants.International journal of molecular sciences · 2020Review
- Sodium Transporters in Human Health and Disease.Frontiers in physiology · 2020Review
- Increased Levels of cAMP by the Calcium-Dependent Activation of Soluble Adenylyl Cyclase inCells · 2019Article
- Raman Spectroscopic Analysis of Signaling Molecules-Dopamine Receptors Interactions in Living Cells.ACS omega · 2018Article
- Pharmacological modulation of the COPharmacology & therapeutics · 2018Review
- Importance of bicarbonate transport in pH control during amelogenesis - need for functional studies.Oral diseases · 2018Review
- Role of cAMP and phosphodiesterase signaling in liver health and disease.Cellular signalling · 2018Review
- Adenylyl cyclase 6 is required for maintaining acid-base homeostasis.Clinical science (London, England : 1979) · 2018Article
- Bicarbonate Inhibits Bacterial Growth and Biofilm Formation of Prevalent Cystic Fibrosis Pathogens.Frontiers in microbiology · 2018Article
- Soluble adenylyl cyclase: A novel player in cardiac hypertrophy induced by isoprenaline or pressure overload.PloS one · 2018Article
- Article
- Receptor Protein Tyrosine Phosphatase γ, CO2 Sensing in Proximal Tubule and Acid Base Homeostasis.Journal of the American Society of Nephrology : JASN · 2016Article
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Soluble adenylyl cyclase (sAC) is a source of the second messenger cyclic adenosine 3', 5' monophosphate (cAMP). sAC is directly regulated by bicarbonate (HCO(-) 3) ions. In living cells, HCO(-) 3 ions are in nearly instantaneous equilibrium with carbon dioxide (CO2) and pH due to the ubiquitous presence of carbonic anhydrases. Numerous biological processes are regulated by CO2, HCO(-) 3, and/or pH, and in a number of these, sAC has been shown to function as a physiological CO2/HCO3/pH sensor. In this review, we detail the known pH sensing functions of sAC, and we discuss two highly-studied, pH-dependent pathways in which sAC might play a role.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.