ArticleBiomarkers in cancer2013
An Antibody-based Blood Test Utilizing a Panel of Biomarkers as a New Method for Improved Breast Cancer Diagnosis.
Article in Biomarkers in cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Blood Test for Breast Cancer Associated Auto Antibodies - Improvement of Octava Blood Test
OctavaColon Blood Tests OctavaGold and OctavaSilver - Blood Tests for the Help in Diagnosis of Colon Cancer Clinical Study Protocol
OctavaPink® For Dense Breast After Negative Mammography
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Can serum autoantibodies be a potential early detection biomarker for breast cancer in women? A diagnostic test accuracy review and meta-analysis.Systematic reviews · 2022Pooled it
- Recent Advances in Electrochemical Sensing of Hydrogen Peroxide (HNanomaterials (Basel, Switzerland) · 2022Review
- Autoantibodies as biomarkers for breast cancer diagnosis and prognosis.Frontiers in immunology · 2022Review
- Recent advances in biosensing approaches for point-of-care breast cancer diagnostics: challenges and future prospects.Nanoscale advances · 2021Review
- Mosaic deletion patterns of the human antibody heavy chain gene locus shown by Bayesian haplotyping.Nature communications · 2019Article
- Autoantibodies as Potential Biomarkers in Breast Cancer.Biosensors · 2018Review
- Ultrasensitive optical biosensor for detection of miRNA-155 using positively charged Au nanoparticles.Scientific reports · 2018Article
- Novel and simple electrochemical biosensor monitoring attomolar levels of miRNA-155 in breast cancer.Biosensors & bioelectronics · 2016Article
- Circulating autoantibodies to LGALS3BP: a novel biomarker for cancer.Disease markers · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In order to develop a new tool for diagnosis of breast cancer based on autoantibodies against a panel of biomarkers, a clinical trial including blood samples from 507 subjects was conducted. All subjects showed a breast abnormality on exam or breast imaging and final biopsy pathology of either breast cancer patients or healthy controls. Using an enzyme-linked immunosorbent assay, the samples were tested for autoantibodies against a predetermined number of biomarkers in various models that were used to determine a diagnosis, which was compared to the clinical status. Our new assay achieved a sensitivity of 95.2% [CI = 92.8-96.8%] at a fixed specificity of 49.5%. Receiver-operator characteristic curve analysis showed an area under the curve of 80.1% [CI = 72.6-87.6%]. These results suggest that a blood test which is based on models comprising several autoantibodies to specific biomarkers may be a new and novel tool for improving the diagnostic evaluation of breast cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.