ReviewMedical devices (Auckland, N.Z.)2013
Capsular contracture by silicone breast implants: possible causes, biocompatibility, and prophylactic strategies.
Review in Medical devices (Auckland, N.Z.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 116 citations in OpenAlex.
- Does Patient History Influence Capsular Contracture? An Exploratory Analysis with Machine Learning.Aesthetic plastic surgery · 2026Article
- Tensile and Tear Strength Evaluation of Clean-Grade Silicone with Cellulose Nanocrystals Reinforcement as an Alternative Material for Maxillofacial Prostheses: An Experimental Study.Medical devices (Auckland, N.Z.) · 2026Article
- Periostin mediates collagen production, ECM remodeling and myofibroblast differentiation in breast prosthesis capsule formation.Scientific reports · 2025Article
- Outcomes of ADM-Assisted Implant-based Breast Reconstructions According to Division Types of the Pectoralis Major Muscle.Aesthetic plastic surgery · 2025Article
- A Grading System-Guided Approach to the Severely Contracted Nose.Aesthetic plastic surgery · 2024Article
- Application of Silicone in Ophthalmology: A Review.Materials (Basel, Switzerland) · 2024Review
- Effect of ASC Injection in the Inflammatory Reaction in Silicone Implant Capsule: Animal Model.Plastic and reconstructive surgery. Global open · 2024Article
- Risk factor analysis and clinical experience of treating capsular contracture after prepectoral implant-based breast reconstruction.Gland surgery · 2024Article
- Unveiling the Enigma: Exploring capsular contracture-Unraveling its link with autoimmune disorders and comprehensive examination of predisposing factors.JPRAS open · 2024Review
- Impact of post-operative infection on revision procedures in breast reconstruction: A marketscan database analysis.Journal of plastic, reconstructive & aesthetic surgery : JPRAS · 2024Article
- In situ forming biomaterials as muscle void fillers for the provisional treatment of volumetric muscle loss injuries.Materials today. Bio · 2023Article
- Advances on Capsular Contracture-Prevention and Management Strategies: A Narrative Review of the Literature.Plastic and reconstructive surgery. Global open · 2023Article
- Implantation and tracing of green fluorescent protein-expressing adipose-derived stem cells in peri-implant capsular fibrosis.Stem cell research & therapy · 2023Article
- Autologous Shuffling Lipo-Aspirated Fat Combined Mechanical Stretch in Revision Rhinoplasty for Severe Contractures in Asian Patients.Aesthetic plastic surgery · 2023Article
- Facilitation of adhesion and spreading of endothelial cells on silicone oxide-coated dacron material by microwave-excited low-pressure plasma.Innovative surgical sciences · 2022Article
- Case Report: Improved surgical treatment for breast capsular contracture by the punctiform-incision approach through the nipple.Frontiers in surgery · 2022Article
- Asiaticoside Combined With Carbon Ion Implantation to Improve the Biocompatibility of Silicone Rubber and to Reduce the Risk of Capsule Contracture.Frontiers in bioengineering and biotechnology · 2022Article
- The Role of Soft Robotic Micromachines in the Future of Medical Devices and Personalized Medicine.Micromachines · 2021Review
- A Case Report of Capsular Contracture Immediately Following COVID-19 Vaccination.Aesthetic surgery journal. Open forum · 2021Article
- Implant Fibrosis and the Underappreciated Role of Myofibroblasts in the Foreign Body Reaction.Cells · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The most common implanted material in the human body consists of silicone. Breast augmentation and breast reconstruction using silicone-based implants are procedures frequently performed by reconstructive and aesthetic surgeons. A main complication of this procedure continues to be the development of capsular contracture (CC), displaying the result of a fibrotic foreign body reaction after the implantation of silicone. For many years, experimental and clinical trials have attempted to analyze the problem of its etiology, treatment, and prophylaxis. Different theories of CC formation are known; however, the reason why different individuals develop CC in days or a month, or only after years, is unknown. Therefore, we hypothesize that CC formation, might primarily be induced by immunological mechanisms along with other reasons. This article attempts to review CC formation, with special attention paid to immunological and inflammatory reasons, as well as actual prophylactic strategies. In this context, the word "biocompatibility" has been frequently used to describe the overall biological innocuousness of silicone in the respective studies, although without clear-cut definitions of this important feature. We have therefore developed a new five-point scale with distinct key points of biocompatibility. Hence, this article might provide the basis for ongoing discussion in this field to reduce single-publication definitions as well as increase the understanding of biocompatibility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.