ArticleProceedings of the National Academy of Sciences of the United States of America2013
Genome differentiation of Drosophila melanogaster from a microclimate contrast in Evolution Canyon, Israel.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Response of Protein Coding Genes and microRNAs to Temperature Changes in Four Species of Drosophilids.Genome biology and evolution · 2026Article
- Experimental evolution-induced transcriptome and phenotype responses of Drosophila melanogaster to novel thermal environments.The Journal of experimental biology · 2025Article
- Scattered differentiation of unlinked loci across the genome underlines ecological divergence of the selfing grassProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Comparative gene retention analysis in barley, wild emmer, and bread wheat pangenome lines reveals factors affecting gene retention following gene duplication.BMC biology · 2023Article
- Article
- Sympatric speciation of wild emmer wheat driven by ecology and chromosomal rearrangements.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Transcriptome-Wide Patterns of the Genetic and Expression Variations in Two Sympatric Schizothoracine Fishes in a Tibetan Plateau Glacier Lake.Genome biology and evolution · 2020Article
- Aggression and courtship differences found in Drosophila melanogaster from two different microclimates at Evolution Canyon, Israel.Scientific reports · 2019Article
- Rapid seasonal evolution in innate immunity of wildProceedings. Biological sciences · 2018Article
- A Large Panel of Drosophila simulans Reveals an Abundance of Common Variants.Genome biology and evolution · 2018Article
- Review
- Regulation of gene expression and RNA editing in Drosophila adapting to divergent microclimates.Nature communications · 2017Article
- Article
- Adaptive differentiation coincides with local bioclimatic conditions along an elevational cline in populations of a lichen-forming fungus.BMC evolutionary biology · 2017Article
- Article
- Article
- Sympatric speciation of spiny mice, Acomys, unfolded transcriptomically at Evolution Canyon, Israel.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Putative adaptive inter-slope divergence of transposon frequency in fruit flies (Drosophila melanogaster) at "Evolution Canyon", Mount Carmel, Israel.Biology direct · 2015Article
- Lack of population differentiation patterns of previously identified putatively adaptive transposable element insertions at microgeographic scales.Biology direct · 2015Article
- Identifying signatures of sexual selection using genomewide selection components analysis.Ecology and evolution · 2015Article
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The opposite slopes of "Evolution Canyon" in Israel have served as a natural model system of adaptation to a microclimate contrast. Long-term studies of Drosophila melanogaster populations inhabiting the canyon have exhibited significant interslope divergence in thermal and drought stress resistance, candidate genes, mobile elements, habitat choice, mating discrimination, and wing-shape variation, all despite close physical proximity of the contrasting habitats, as well as substantial interslope migration. To examine patterns of genetic differentiation at the genome-wide level, we used high coverage sequencing of the flies' genomes. A total of 572 genes were significantly different in allele frequency between the slopes, 106 out of which were associated with 74 significantly overrepresented gene ontology (GO) terms, particularly so with response to stimulus and developmental and reproductive processes, thus corroborating previous observations of interslope divergence in stress response, life history, and mating functions. There were at least 37 chromosomal "islands" of interslope divergence and low sequence polymorphism, plausible signatures of selective sweeps, more abundant in flies derived from one (north-facing) of the slopes. Positive correlation between local recombination rate and the level of nucleotide polymorphism was also found.
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