ArticleProceedings of the National Academy of Sciences of the United States of America2013
Restoration of function after brain damage using a neural prosthesis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers.
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Who cites it
108 citing papers in PubMed, 227 citations in OpenAlex.
- Brain-actuated functional electrical stimulation elicits lasting arm motor recovery after stroke.Nature communications · 2018Trial
- Towards neuromorphic neurotechnologies: integrating brain-inspired computing with brain-computer interfaces.npj biomedical innovations · 2026Review
- Engineering Neuronal Network Connectivity Through Precise and Scalable Electrical Modulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Peripheral nerve pathway reconnections promote the reorganization of central motor representations.Science China. Life sciences · 2026Article
- Conserved role of primary motor cortex in the control of prehension in mice and macaques.Cell reports · 2026Article
- An antiswelling biodegradable hydrogel reshapes electro-microenvironment to drive endogenous neuroregeneration after brain defect.Science advances · 2026Article
- logLIRA: a method for reliable suppression of electrical stimulation artifacts enabling short-latency neural response recovery.Journal of neural engineering · 2026Article
- Review
- A Bidirectional Neural Interface With Direct On-Device Neuromorphic Decoding for Closed-Loop Optogenetics.bioRxiv : the preprint server for biology · 2026Article
- Controlled release of bone morphogenetic protein-2 improves motor function after traumatic brain injury in a rat model.Journal of materials chemistry. B · 2026Article
- Advancing neuroengineering with Neuromorphic Twins.Nature communications · 2026Review
- Shared somatosensory-motor neural population dynamics track motor recovery after stroke.bioRxiv : the preprint server for biology · 2026Article
- Intracortical Microstimulation in Brain-Computer Interfaces: Evoking Perception and Plasticity.Cyborg and bionic systems (Washington, D.C.) · 2026Review
- Spiking neural networks provide accurate and time-efficient models for whisker stimulus classification of the awake mouse.Frontiers in neuroscience · 2026Article
- Restoration of temporal separability between beta and movement ensemble co-firing with motor recovery.Neuron · 2025Article
- Absence of cortical reorganization following an internal capsule stroke in rodents.bioRxiv : the preprint server for biology · 2025Article
- Effective cerebellar neuroprosthetic control after stroke.Cell reports · 2025Article
- Enabling Model-Based Design for Real-Time Spike Detection.IEEE open journal of engineering in medicine and biology · 2025Article
- Impact of ischemic lesion on sleep related connectivity in the sensorimotor cortex.Frontiers in neuroscience · 2025Article
- Review
48 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neural interface systems are becoming increasingly more feasible for brain repair strategies. This paper tests the hypothesis that recovery after brain injury can be facilitated by a neural prosthesis serving as a communication link between distant locations in the cerebral cortex. The primary motor area in the cerebral cortex was injured in a rat model of focal brain injury, disrupting communication between motor and somatosensory areas and resulting in impaired reaching and grasping abilities. After implantation of microelectrodes in cerebral cortex, a neural prosthesis discriminated action potentials (spikes) in premotor cortex that triggered electrical stimulation in somatosensory cortex continuously over subsequent weeks. Within 1 wk, while receiving spike-triggered stimulation, rats showed substantially improved reaching and grasping functions that were indistinguishable from prelesion levels by 2 wk. Post hoc analysis of the spikes evoked by the stimulation provides compelling evidence that the neural prosthesis enhanced functional connectivity between the two target areas. This proof-of-concept study demonstrates that neural interface systems can be used effectively to bridge damaged neural pathways functionally and promote recovery after brain injury.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.