ArticleProceedings of the National Academy of Sciences of the United States of America2013
Biased migration of confined neutrophil-like cells in asymmetric hydraulic environments.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
What it found
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Who cites it
68 citing papers in PubMed.
- Nonlinear distributed sensing of light patterns leads to perceptual distortions in plants.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Adaptive motility enables neutrophils to rapidly navigate confined capillaries.Science immunology · 2026Article
- Leukocyte-epithelial physical contacts mediate interstitial migration in vivo.Research square · 2026Article
- Leveraging agent-based models and deep reinforcement learning to predict taxis in cell migration.NPJ systems biology and applications · 2025Article
- Confinement by Liquid-Liquid Interface Replicates In Vivo Neutrophil Deformations and Elicits Bleb-Based Migration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Circulating Tumor Microenvironment in Metastasis.Cancer research · 2025Review
- Trade-off movement between hydraulic resistance escape and shear stress escape by cancer cells.Biophysical journal · 2025Article
- Physical principles and mechanisms of cell migration.npj biological physics and mechanics · 2025Review
- The role of dynamic reciprocity in 3D cell migration: connecting cell and matrix mechanics to migratory plasticity.npj biological physics and mechanics · 2025Review
- Confinement controls the directional cell responses to fluid forces.Cell reports · 2024Article
- Profiling migration of human monocytes in response to chemotactic and barotactic guidance cues.Cell reports methods · 2024Article
- The impact of tumor microenvironment: unraveling the role of physical cues in breast cancer progression.Cancer metastasis reviews · 2024Review
- Regulation of cell fate by cell imprinting approach in vitro.BioImpacts : BI · 2024Review
- Subcellular mechano-regulation of cell migration in confined extracellular microenvironment.Biophysics reviews · 2023Review
- A Comparative Inflammation-on-a-Chip with a Complete 3D Interface: Pharmacological Applications in COPD-Induced Neutrophil Migration.Advanced healthcare materials · 2023Article
- The cell's dilemma: resolving directional decisions.Trends in immunology · 2023Article
- Leading edge competition promotes context-dependent responses to receptor inputs to resolve directional dilemmas in neutrophil migration.Cell systems · 2023Article
- Assessing cell migration in hydrogels: An overview of relevant materials and methods.Materials today. Bio · 2023Review
- Ameboid cell migration through regular arrays of micropillars under confinement.Biophysical journal · 2022Article
- Keratocytes migrate against flow with a roly-poly-like mechanism.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Cells integrate multiple measurement modalities to navigate their environment. Soluble and substrate-bound chemical gradients and physical cues have all been shown to influence cell orientation and migration. Here we investigate the role of asymmetric hydraulic pressure in directional sensing. Cells confined in microchannels identified and chose a path of lower hydraulic resistance in the absence of chemical cues. In a bifurcating channel with asymmetric hydraulic resistances, this choice was preceded by the elaboration of two leading edges with a faster extension rate along the lower resistance channel. Retraction of the "losing" edge appeared to precipitate a final choice of direction. The pressure differences altering leading edge protrusion rates were small, suggesting weak force generation by leading edges. The response to the physical asymmetry was able to override a dynamically generated chemical cue. Motile cells may use this bias as a result of hydraulic resistance, or "barotaxis," in concert with chemotaxis to navigate complex environments.
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Registered trials
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