One hundred years of somatic mutation theory of carcinogenesis: is it time to switch?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

13 citing papers in PubMed.

1. Hypoxic adaptation theory of cancer.Frontiers in cell and developmental biology · 2026
   Article
2. Initiation of Cancer: The Journey From Mutations in Somatic Cells to Epigenetic Changes in Tissue-resident VSELs.Stem cell reviews and reports · 2024
   Review
3. Paradoxical Behavior of Oncogenes Undermines the Somatic Mutation Theory.Biomolecules · 2022
   Article
4. Mutation or not, what directly establishes a neoplastic state, namely cellular immortality and autonomy, still remains unknown and should be prioritized in our research.Journal of Cancer · 2022
   Review
5. Over a century of cancer research: Inconvenient truths and promising leads.PLoS biology · 2020
   Article
6. Ion Channel and Neurotransmitter Modulators as Electroceutical Approaches to the Control of Cancer.Current pharmaceutical design · 2017
   Review
7. Broad Spectrum Anticancer Activity of Myo-Inositol and Inositol Hexakisphosphate.International journal of endocrinology · 2016
   Review
8. Cancer Metastases: So Close and So Far.Journal of the National Cancer Institute · 2015
   Article
9. Cancer research in need of a scientific revolution: Using 'paradigm shift' as a method of investigation.Journal of biosciences · 2015
   Review
10. Evidence for DNA damage as a biological link between diabetes and cancer.Chinese medical journal · 2015
    Review
11. Just like the rest of evolution in Mother Nature, the evolution of cancers may be driven by natural selection, and not by haphazard mutations.Oncoscience · 2014
    Article
12. Tumor and the microenvironment: a chance to reframe the paradigm of carcinogenesis?BioMed research international · 2014
    Review
13. Changing the Paradigm of Cancer Screening, Prevention, and Treatment.Dose-response : a publication of International Hormesis Society
    Article

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

2 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

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