ReviewTranslational stroke research2014
Inflammation and cerebral aneurysms.
Review in Translational stroke research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
78 citing papers in PubMed, 3 syntheses or guidelines pooled it, 124 citations in OpenAlex.
- The association between hematologic traits and aneurysm-related subarachnoid hemorrhage: a two-sample mendelian randomization study.Scientific reports · 2024Pooled it
- In the wall lies the truth: a systematic review of diagnostic markers in intracranial aneurysms.Brain pathology (Zurich, Switzerland) · 2020Pooled it
- What does computational fluid dynamics tell us about intracranial aneurysms? A meta-analysis and critical review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Pooled it
- Intracranial aneurysms as a manifestation of premature vascular aging: Cellular senescence, inflammaging, and wall degeneration.Ageing research reviews · 2026Review
- Circumferential wall enhancement is associated with neutrophil-to-lymphocyte ratio in intracranial fusiform aneurysms.Neuroradiology · 2026Article
- A wide-necked saccular aneurysm of the middle cerebral artery bifurcation with neck atherosclerosis mimicking a fusiform aneurysm: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Orexin B Reduces Cerebral Aneurysms Through Inhibition of SP-1.CNS neuroscience & therapeutics · 2026Article
- Identifying the role of aging-related genes in intracranial aneurysms through bioinformatics analysis.Chinese neurosurgical journal · 2025Article
- Inverse Association between the Body Mass Index and the Incidence of Unruptured Intracranial Aneurysms-Insights from the Hamburg City Health Population Study.Translational stroke research · 2025Article
- Integrating mental health and cardiovascular wellness: synergistic impacts and the promise of comprehensive care models.Annals of medicine and surgery (2012) · 2025Review
- Inflammatory Biomarkers as Prognostic Indicators for Intracranial Aneurysm Recurrence After Stent-Assisted Coil Embolization.Immunity, inflammation and disease · 2025Article
- Intracranial Aneurysm Biomarkers: A Convergence of Genetics, Inflammation, Oxidative Stress, and the Extracellular Matrix.International journal of molecular sciences · 2025Review
- T cells immune imbalance presents in patients with multiple intracranial aneurysms.Clinical and experimental immunology · 2025Article
- Predictive value of the systemic immune-inflammation index for periprocedural complications in flow diverter treatment for patients with intracranial aneurysms.Neurosurgical review · 2024Article
- Multiomics integrated analysis and experimental validation identify TLR4 and ALOX5 as oxidative stress-related biomarkers in intracranial aneurysms.Journal of neuroinflammation · 2024Article
- Nesfatin-1 inhibits cerebral aneurysms by activating Nrf2 and inhibiting NF-κB signaling.CNS neuroscience & therapeutics · 2024Article
- Aspirin treatment for unruptured intracranial aneurysms: Focusing on its anti-inflammatory role.Heliyon · 2024Review
- Article
- Targeting myeloperoxidase to stabilize unruptured aneurysm: an imaging-guided approach.BMC cardiovascular disorders · 2024Article
- Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cerebral aneurysms (CAs) occur in up to 5% of the population in the US, and up to 7% of all strokes are caused by CA rupture. Little is known about the pathophysiology of cerebral aneurysm formation, though inflammatory cells such as macrophages and neutrophils have been found in the walls of CAs. After many studies of both human specimens and experimentally induced animal models of aneurysms, the predominant model for CA formation and progression is as follows: (1) endothelial damage and degeneration of the elastic lamina, (2) inflammatory cell recruitment and infiltration, (3) and chronic remodeling of vascular wall. Endothelial damage can be caused by changes in hemodynamic stress, which results in the upregulation of proinflammatory cytokine secretion followed by the recruitment of various inflammatory cells. This recruitment and subsequent infiltration induces smooth muscle cell proliferation, apoptosis, and remodeling of the artery wall. These complex events are thought to lead to aneurysm rupture. This review will focus on the role of the immune system in the formation and progression of saccular CA and the ways in which the immune response may be modulated to treat aneurysms and prevent rupture.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.