ArticleCognitive, affective & behavioral neuroscience2014
Dopamine modulates frontomedial failure processing of agentic introverts versus extraverts in incentive contexts.
Article in Cognitive, affective & behavioral neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 86 citations in OpenAlex.
- Individual differences in dopamine-related traits influence mood effects of dopamine D2-antagonist and antidepressant treatment expectations.The international journal of neuropsychopharmacology · 2025Trial
- Alpha-2 Adrenoreceptor Antagonist Yohimbine Potentiates Consolidation of Conditioned Fear.The international journal of neuropsychopharmacology · 2022Trial
- Event-related potentials reflect impaired temporal interval learning following haloperidol administration.Psychopharmacology · 2017Trial
- Developmental trajectories of sensitivity to threat in children and adolescents predict larger medial frontal theta differentiation during response inhibition.Social cognitive and affective neuroscience · 2023Article
- Amphetamine alters an EEG marker of reward processing in humans and mice.Psychopharmacology · 2022Article
- Is Adolescence a Sensitive Period for the Development of Incentive-Reward Motivation?Current topics in behavioral neurosciences · 2022Review
- Does openness/intellect predict sensitivity to the reward value of information?Cognitive, affective & behavioral neuroscience · 2021Article
- The Selective Dopamine D2 Blocker Sulpiride Modulates the Relationship Between Agentic Extraversion and Executive Functions.Cognitive, affective & behavioral neuroscience · 2021Article
- Dose-response effects of d-amphetamine on effort-based decision-making and reinforcement learning.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- A Revised Framework for the Investigation of Expectation Update Versus Maintenance in the Context of Expectation Violations: The ViolEx 2.0 Model.Frontiers in psychology · 2021Article
- Using pharmacological manipulations to study the role of dopamine in human reward functioning: A review of studies in healthy adults.Neuroscience and biobehavioral reviews · 2021Review
- From Description to Explanation: Integrating Across Multiple Levels of Analysis to Inform Neuroscientific Accounts of Dimensional Personality Pathology.Journal of personality disorders · 2020Article
- Developmental trajectories to reduced activation of positive valence systems: A review of biological and environmental contributions.Developmental cognitive neuroscience · 2020Review
- A low dosage of the dopamine D2-receptor antagonist sulpiride affects effort allocation for reward regardless of trait extraversion.Personality neuroscience · 2020Article
- Social context effects on error-related brain activity are dependent on interpersonal and achievement-related traits.Scientific reports · 2019Article
- Fear Extinction Recall Modulates Human Frontomedial Theta and Amygdala Activity.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Openness to experience predicts dopamine effects on divergent thinking.Personality neuroscience · 2019Article
- Thumbs up or thumbs down? Effects of neuroticism and depressive symptoms on psychophysiological responses to social evaluation in healthy students.Cognitive, affective & behavioral neuroscience · 2016Article
- Face-induced expectancies influence neural mechanisms of performance monitoring.Cognitive, affective & behavioral neuroscience · 2016Article
- Potentiated processing of negative feedback in depression is attenuated by anhedonia.Depression and anxiety · 2015Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The agency facet of extraversion (aE) describes individual differences in goal-directed behavior and has been linked to dopamine function in incentive contexts. Because dopamine presumably modulates the processing of negative feedback/failure, aE may relate to failure processing in incentive contexts. To test this hypothesis, N = 86 participants performed a virtual ball-catching task. An incentive context was created by displaying potential rewards and subtle manipulations of task performance, which either was (control group) or was not (incentive context group) made explicit. To probe the involvement of dopamine, participants received either placebo or the selective dopamine D2 receptor antagonist sulpiride (200 mg). Failure processing was assessed through negative-feedback-evoked differences in the frontal midline theta electroencephalogram power (DFMT) and in the feedback-related negativity event-related potential component (FRN). Before incentives were introduced, DFMT (but not the FRN) was related to neuroticism/anxiety. Importantly, once incentives were displayed, aE was associated with DFMT, FRN, task performance, and changes in self-reported positive affect, which further depended on incentive context group and/or substance group: In the incentive context group but not in the control group, agentic extraverts showed relatively blunted DFMT after placebo. Sulpiride significantly enhanced DFMT, whereas it reduced FRN amplitudes and performance in agentic extra- versus introverts. These findings provide strong support for current dopamine models of aE and failure processing, and also highlight the importance of task context. Moreover, the dissociations of FRN and DFMT suggest the existence of two nonredundant electrophysiological indices of feedback processing, both relating to dopamine and aE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.