ArticleAntimicrobial agents and chemotherapy2014
Emergence of Escherichia coli sequence type 131 isolates producing KPC-2 carbapenemase in China.
Article in Antimicrobial agents and chemotherapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Global Extraintestinal Pathogenic Escherichia coli (ExPEC) Lineages.Clinical microbiology reviews · 2019Pooled it
- Epidemiology and Mechanism of Drug Resistance of Multidrug-Resistant Klebsiella Pneumoniae Isolated from Patients with Urinary Tract Infection in Beijing Teaching Hospital, China.Infection and drug resistance · 2025Article
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- Allele distribution and phenotypic resistance to ciprofloxacin and gentamicin among extended-spectrum β-lactamase-producingFrontiers in antibiotics · 2023Article
- Genomic data reveals the emergence of an IncQ1 small plasmid carrying blaJournal of global antimicrobial resistance · 2021Article
- Carbapenem-ResistantInfection and drug resistance · 2021Article
- Co-harboring of NovelFrontiers in microbiology · 2021Article
- Molecular Epidemiology ofInfection and drug resistance · 2021Article
- Activity of Cefiderocol, Ceftazidime-Avibactam, and Eravacycline against Carbapenem-Resistant Escherichia coli Isolates from the United States and International Sites in Relation to Clonal Background, Resistance Genes, Coresistance, and Region.Antimicrobial agents and chemotherapy · 2020Article
- Activity of Imipenem-Relebactam against Carbapenem-Resistant Escherichia coli Isolates from the United States in Relation to Clonal Background, Resistance Genes, Coresistance, and Region.Antimicrobial agents and chemotherapy · 2020Article
- Emergence of KPC-2-Producing Raoultella ornithinolytica Isolated from a Hospital Wastewater Treatment Plant.Antimicrobial agents and chemotherapy · 2020Article
- Environmental Presence and Genetic Characteristics of Carbapenemase-ProducingApplied and environmental microbiology · 2020Article
- First Indian report on genome-wide comparison of multidrug-resistant Escherichia coli from blood stream infections.PloS one · 2020Article
- The anti-virulence effect of cranberry active compound proanthocyanins (PACs) on expression of genes in the third-generation cephalosporin-resistantAntimicrobial resistance and infection control · 2019Article
- A novel plasmid carrying carbapenem-resistant geneInfection and drug resistance · 2019Article
- Molecular characterization and epidemiology of carbapenem non-susceptible Enterobacteriaceae isolated from the Eastern region of Heilongjiang Province, China.BMC infectious diseases · 2018Article
- Multidrug-resistant Citrobacter freundii ST139 co-producing NDM-1 and CMY-152 from China.Scientific reports · 2018Article
- Carbapenemase-producing Enterobacteriaceae in Mexico: report of seven non-clonal cases in a pediatric hospital.BMC microbiology · 2018Article
- Characteristics of diarrheagenic Escherichia coli among children under 5 years of age with acute diarrhea: a hospital based study.BMC infectious diseases · 2018Article
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Authors and funding
5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Twenty-two KPC-2-producing Escherichia coli isolates were obtained from three hospitals in Hangzhou, China, from 2007 to 2011. One isolate, with OmpC porin deficiency, exhibited high-level carbapenem resistance. Pulsed-field gel electrophoresis showed that few isolates were indistinguishable or closely related. Multilocus sequence typing indicated that sequence type 131 (ST131) was the predominant type (9 isolates, 40.9%), followed by ST648 (5 isolates), ST405 (2 isolates), ST38 (2 isolates), and 4 single STs, ST69, ST2003, ST2179, and ST744. Phylogenetic analysis indicated that 9 group B2 isolates belonged to ST131, and 5 of 11 group D isolates belonged to ST648. Only one group B1 isolate and one group A isolate were identified. A representative plasmid (pE1) was partially sequenced, and a 7,788-bp DNA fragment encoding Tn3 transposase, Tn3 resolvase, ISKpn8 transposase, KPC-2, and ISKpn6-like transposase was obtained. The blaKPC-2-surrounding sequence was amplified by a series of primers. The PCR results showed that 13 isolates were consistent with the genetic environment in pE1. It is the first report of rapid emergence of KPC-2-producing E. coli ST131 in China. The blaKPC-2 gene of most isolates was located on a similar genetic structure.
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