ReviewNeurotoxicity research2014
A critical evaluation of behavioral rodent models of motor impairment used for screening of antiparkinsonian activity: The case of adenosine A(2A) receptor antagonists.
Review in Neurotoxicity research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 24 citations in OpenAlex.
- ACells · 2025Article
- Animal models of L-DOPA-induced dyskinesia: the 6-OHDA-lesioned rat and mouse.Journal of neural transmission (Vienna, Austria : 1996) · 2018Review
- Role of adenosine AJournal of neural transmission (Vienna, Austria : 1996) · 2018Review
- Tremorolytic effect of 5'-chloro-5'-deoxy-(±)-ENBA, a potent and selective adenosine A1 receptor agonist, evaluated in the harmaline-induced model in rats.CNS neuroscience & therapeutics · 2017Article
- Dihydromyricetin protects neurons in an MPTP-induced model of Parkinson's disease by suppressing glycogen synthase kinase-3 beta activity.Acta pharmacologica Sinica · 2016Article
- Nondopaminergic treatments for Parkinson's disease: current and future prospects.Neurodegenerative disease management · 2016Review
- Activation of adenosine A₂A receptors suppresses the emission of pro-social and drug-stimulated 50-kHz ultrasonic vocalizations in rats: possible relevance to reward and motivation.Psychopharmacology · 2016Article
- Behavioral phenotyping of Parkin-deficient mice: looking for early preclinical features of Parkinson's disease.PloS one · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Animal models of motor dysfunction constitute the basis for the screening of new drugs with potential efficacy in diseases characterized by motor impairment, such as Parkinson's Disease (PD). Taking adenosine A(2A) receptor antagonists as an example of a new class of drugs for PD, the review will examine the most utilized rodent models of motor impairment and the results reported in the literature with this class of drugs. The results obtained so far in rodent models of PD suggested that A(2A) receptor antagonists might have symptomatic therapeutic efficacy in PD. They may ameliorate initiation of movement, gait and muscle rigidity, sensorimotor integration deficits, and tremor. Moreover, A(2A) receptor antagonists when administered with a low sub-threshold dose of L-DOPA potentiated its efficacy. However, the clinical trials so far performed have evaluated their efficacy in the "ON/OFF" of PD patients with motor complications, showing a limited efficacy of this class of drug. Therefore, on one hand, animal models of PD might have a limited validity; on the other hand, clinical trials should explore the efficacy of A(2A) receptor antagonists on a broader range of parkinsonian conditions.
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