ArticleSocial psychiatry and psychiatric epidemiology2014
Gene-environment interactions in common mental disorders: an update and strategy for a genome-wide search.
Article in Social psychiatry and psychiatric epidemiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genome-wide association meta-analysis of age at first cannabis use.Addiction (Abingdon, England) · 2018Pooled it
- A familial risk enriched cohort as a platform for testing early interventions to prevent severe mental illness.BMC psychiatry · 2014Trial
- Associations of personality profiles with stress and resilience characteristics among patients undergoing cancer chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Observational
- The role of gene-environment interactions in endocrine-sensitive life stages for shaping mental health: focus on the RE-MEND project.Frontiers in psychiatry · 2026Review
- The influence of genetic factors on the severity of anxiety and depressive symptoms and the choice of coping strategies in reproductive tract cancer-a preliminary study.Frontiers in public health · 2025Article
- Advances in the prevalence and treatment of depression for adolescents: a review.Frontiers in pharmacology · 2025Review
- Socioeconomic position interacts with the genetic effect of a CRP gene common variant to influence C-reactive protein values.Scientific reports · 2024Article
- BMAL1-Potential Player of Aberrant Stress Response in Q31L Mice Model of Affective Disorders: Pilot Results.International journal of molecular sciences · 2024Article
- The association between trauma exposure, polygenic risk and individual depression symptoms.Psychiatry research · 2023Article
- Genetic Risk Assessment in Psychiatry.Cold Spring Harbor perspectives in medicine · 2020Review
- Multiple plasma metals, genetic risk and serum C-reactive protein: A metal-metal and gene-metal interaction study.Redox biology · 2020Article
- Influence of childhood trauma and brain-derived neurotrophic factor Val66Met polymorphism on posttraumatic stress symptoms and cortical thickness.Scientific reports · 2019Article
- Article
- Sleep in Offspring of Parents With Mood Disorders.Frontiers in psychiatry · 2019Article
- The Food-Specific Serum IgG Reactivity in Major Depressive Disorder Patients, Irritable Bowel Syndrome Patients and Healthy Controls.Nutrients · 2018Article
- The functional highly sensitive brain: a review of the brain circuits underlying sensory processing sensitivity and seemingly related disorders.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Pharmacogenomics study of thiazide diuretics and QT interval in multi-ethnic populations: the cohorts for heart and aging research in genomic epidemiology.The pharmacogenomics journal · 2018Article
- Genetic variants in 5-HTTLPR, BDNF, HTR1A, COMT, and FKBP5 and risk for treated depression after cancer diagnosis.Depression and anxiety · 2017Article
- Anticipating the Ethical Challenges of Psychiatric Genetic Testing.Current psychiatry reports · 2017Review
- Etiology in psychiatry: embracing the reality of poly-gene-environmental causation of mental illness.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2017Article
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Abstract
A decade of research has demonstrated the explanatory potential of interplay between genetic variants and environmental factors in the development of common mental disorders. Initial findings have undergone tests of replicability and specificity. Some gene-environment interactions have been confirmed, some have not replicated and yet other turned out to be more specific than initially thought. Specific and complementary roles of genetic factors have been delineated: a common functional length polymorphism in the serotonin transporter gene (5-HTTLPR) moderated the effect of childhood maltreatment on chronic depression in adulthood, but did not substantially influence the effects of adult stressful life events on the onset of new depressive episodes; in contrast, a common functional polymorphism in the brain-derived neurotrophic factor gene (BDNF) moderated the effect of stressful life events in adulthood in triggering new depressive episodes, but did not influence the effects of childhood maltreatment. Molecular mechanisms underlying gene-environment interactions are being uncovered, including DNA methylation and other epigenetic modifications. New gene-environment interactions continue to be reported, still largely from hypothesis-driven research. Statistical and biological prioritization strategies are proposed to facilitate a systematic discovery of novel gene-environment interactions in genome-wide analyses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.