Evidence map›Paper›PMID 24323244›Full record

Trial reportJournal of neurology2014

Randomized controlled trial of physical activity, cognition, and walking in multiple sclerosis.

Brian M Sandroff, Rachel E Klaren, Lara A Pilutti, Deirdre Dlugonski, Ralph H B Benedict, Robert W Motl

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06341023 (Functional Balance Intervention), which is not on this map. Cited by 37 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 7 pooled it
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06341023 narecruitingnot on this mapstarted 2025, after this paper: background citation

Functional Balance Intervention (FBI) for Physical and Cognitive Symptoms of Multiple Sclerosis

TypeinterventionalSponsorUniversity of Illinois at ChicagoRan2025 to 2027Enrolled120ConditionsMultiple SclerosisArmsFunctional Balance Intervention, Stretching
3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 7 syntheses or guidelines pooled it, 112 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Interventions for preventing falls in people with multiple sclerosis.The Cochrane database of systematic reviews · 2019
    Pooled it
  6. Pooled it
  7. Telerehabilitation for persons with multiple sclerosis.The Cochrane database of systematic reviews · 2015
    Pooled it
  8. Trial
  9. Trial
  10. Trial
  11. Psychometric properties of quality of life and health-related quality of life assessments in people with multiple sclerosis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2014
    Trial
  12. Article
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  14. Review
  15. Article
  16. Review
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Brian M SandroffDepartment of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, 233 Freer Hall, 906 South Goodwin Ave., Urbana, IL, 61801, USA.
Rachel E Klaren
Lara A Pilutti
Deirdre Dlugonski
Ralph H B Benedict
Robert W Motl
University of Illinois Urbana-Champaign · USUniversity at Buffalo, State University of New York · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study adopted a randomized controlled trial design and examined the effect of a physical activity behavioral intervention on cognitive and walking performance among persons with MS who have mild or moderate disability status. A total of 82 MS patients were randomly allocated into intervention or wait-list control conditions. The intervention condition received a theory-based program for increasing physical activity behavior that was delivered via the Internet, and one-on-one video chat sessions with a behavior-change coach. Participants completed self-report measures of physical activity and disability status, and underwent the oral Symbol Digit Modalities Test (SDMT) and 6-minute walk (6MW) test before and after the 6-month period. Analysis using mixed-model ANOVA indicated a significant time × condition × disability group interaction on SDMT scores (p = 0.02, partial-η (2) = 0.08), such that persons with mild disability in the intervention condition demonstrated a clinically meaningful improvement in SDMT scores (~6 point change). There was a further significant time × condition interaction on 6MW distance (p = 0.02, partial-η (2) = 0.07), such that those in the intervention condition demonstrated an increase in 6MW distance relative to those in the control group. The current study supports physical activity as a promising tool for managing cognitive impairment and impaired walking performance in persons with MS, and suggests that physical activity might have specific effects on cognition and non-specific effects on walking performance in this population.

Indexed as

AdultCognitionData Interpretation, StatisticalDisability EvaluationExercise TherapyFemaleHumansMaleMiddle AgedMotor ActivityMultiple SclerosisNeuropsychological TestsPatient CompliancePsychomotor PerformanceTreatment OutcomeWalking

Identifiers

PMID24323244
OpenAlexW2031878678

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.