ReviewTranslational stroke research2013
Epigenetics and the environment: in search of the "toleroasome" vital to execution of ischemic preconditioning.
Review in Translational stroke research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 12 citations in OpenAlex.
- Factors influencing brain recovery from stroke via possible epigenetic changes.Future science OA · 2024Review
- Estrogen preconditioning: A promising strategy to reduce inflammation in the ischemic brain.Conditioning medicine · 2019Article
- Regulation of gene expression in ischemic preconditioning in the brain.Conditioning medicine · 2017Article
- Isometric Exercise Training for Managing Vascular Risk Factors in Mild Cognitive Impairment and Alzheimer's Disease.Frontiers in aging neuroscience · 2017Review
- Remote limb ischemic conditioning enhances motor learning in healthy humans.Journal of neurophysiology · 2015Article
- Extending injury- and disease-resistant CNS phenotypes by repetitive epigenetic conditioning.Frontiers in neurology · 2015Review
- Full steam ahead with remote ischemic conditioning for stroke.Translational stroke research · 2014Article
- Epigenetics and nutritional environmental signals.Integrative and comparative biology · 2014Review
- Fetal asphyctic preconditioning alters the transcriptional response to perinatal asphyxia.BMC neuroscience · 2014Article
- SIRT1 regulation modulates stroke outcome.Translational stroke research · 2013Review
- Fetal brain genomic reprogramming following asphyctic preconditioning.BMC neuroscience · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Activation and repression of gene expression are key features of ischemic tolerance. Converging lines of inquiry from several groups suggests that epigenetic proteins may transduce sublethal stresses, including bioenergetic or oxidative stress into durable (2-3 days) changes in gene expression that mediate ischemic tolerance. Here we discuss the potential mechanisms by which changes in cell state (e.g., ATP, NAD+, and oxygen) can modify specific targets including polycomb complexes, jumonji domain histone demethylases, and zinc and NAD-dependent histone decetylases and thus trigger an adaptive program. A major unanswered question is whether these proteins work in parallel or convergently as part of a "tolerosome" (tolero is the Latin word for tolerance), a multiprotein complex recruited to promoters or enhancers of specific genes, to mediate preconditioning. Whatever the case may be, epigenetic proteins are fertile targets for the treatment of stroke.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.