ReviewNature reviews. Rheumatology2014
Ocular inflammatory diseases associated with rheumatoid arthritis.
Review in Nature reviews. Rheumatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 142 citations in OpenAlex.
- Role of Janus Kinase (JAK) Inhibitor in Autoimmune Ocular Inflammation: A Systematic Review.Journal of immunology research · 2021Pooled it
- Ocular IL-1α/IFN-γ Delay the Corneal Wound Healing in Rheumatoid Arthritis Through Mitochondrial Dysfunction and NLRP3 Inflammasome Activation.Investigative ophthalmology & visual science · 2026Article
- An Overview of Rheumatoid Arthritis-Associated Dry Eye Disease, Scleritis, and Peripheral Ulcerative Keratitis.Journal of clinical medicine · 2026Review
- A case report: corneal melting after patch graft in a rheumatoid arthritis patient taking Upadacitinib: paradoxical manifestation or uncontrolled disease activity?BMC ophthalmology · 2025Article
- The "sandwich" procedure for paracentral rheumatoid corneal perforation: a case report with 6-year follow-up and literature review.Frontiers in medicine · 2025Article
- Therapeutic potential of peptidomimetics of suppressors of cytokine signaling (SOCS) proteins in rheumatic disorders.Frontiers in medicine · 2025Article
- Post-Operative Complications After Cataract Surgery in Patients with Rheumatoid Arthritis and/or Sjögren's Syndrome.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Is there a paradoxical side effect? Is it a case of inefficiency? Peripheral ulcerative keratitis in a patient with rheumatoid arthritis in remission treated with tocilizumab.Turkish journal of physical medicine and rehabilitation · 2024Article
- Eye Disease in Patients with Rheumatic Diseases: A Retrospective Observational Cohort Study.Journal of clinical medicine · 2023Article
- Autoimmune Disease-Related Dry Eye Diseases and Their Placement Under the Revised Classification Systems: An Update.Cureus · 2023Review
- Investigation of altered retinal microvasculature in female patients with rheumatoid arthritis: optical coherence tomography angiography detection.Bioscience reports · 2023Article
- Diagnostic Performance of the Tear Meniscus Osmolarity Measurement for Dry Eye Disease in Rheumatoid Arthritis Patients.Diagnostics (Basel, Switzerland) · 2023Article
- Hydroxychloroquine is neutral on incidental cataracts in patients with rheumatoid arthritis.Scientific reports · 2023Article
- Identifying TNF and IL6 as potential hub genes and targeted drugs associated with scleritis: A bio-informative report.Frontiers in immunology · 2023Article
- A novel technique of full-thickness scleral debridement in fulminant necrotising infectious scleritis and its outcomes-a consecutive case series.International ophthalmology · 2022Article
- Associations between Sjögren Syndrome, Sociodemographic Factors, Comorbid Conditions, and Scleritis in a Taiwanese Population-Based Study.Journal of personalized medicine · 2022Article
- Peripheral ulcerative keratitis, nodular episcleritis, and pulmonary nodules as the initial signs of rheumatic arthritis: A Case Report.Frontiers in immunology · 2022Article
- Baricitinib in severe and refractory peripheral ulcerative keratitis: a case report and literature review.Therapeutic advances in musculoskeletal disease · 2022Article
- Giant cell arteritis and scleritis: A rare association.Caspian journal of internal medicine · 2022Article
- [Clinical characteristics and risk factors of rheumatoid arthritis with ulcerative keratitis].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The extra-articular complications of rheumatoid arthritis (RA) include ophthalmological manifestations, which can, in some cases, be the first signs of the disease. These inflammatory ophthalmological conditions include episcleritis, scleritis and peripheral ulcerative keratitis (PUK). RA is the leading cause of necrotizing scleritis and of PUK, which are the two most severe ocular conditions associated with the disease. These conditions can rapidly threaten ocular prognosis and are associated with excess mortality in patients with RA owing to their association with systemic vasculitis. Close collaboration between the ophthalmologist and the rheumatologist or internal medicine expert is required for the diagnosis and therapeutic management of these patients. In this Review, we provide an overview of ocular inflammatory diseases in patients with RA with particular focus on the diagnosis and current available therapies (including biologic agents) for these conditions. Furthermore, we propose a decision tree to assist clinicians in their choice of treatment for patients with RA who also have ocular inflammatory disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.