ArticleScientific reports2013
Transcriptional signaling pathways inversely regulated in Alzheimer's disease and glioblastoma multiform.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A Meta-Analysis of Alzheimer's Disease Brain Transcriptomic Data.Journal of Alzheimer's disease : JAD · 2019Pooled it
- Integrated genomic approaches identify major pathways and upstream regulators in late onset Alzheimer's disease.Scientific reports · 2015Pooled it
- Neurological Effects ofNutrients · 2026Article
- The GPCR Connection: Linking Alzheimer's Disease and Glioblastoma.Journal of cellular and molecular medicine · 2026Review
- Article
- Quantifying the activity profile of ASO and siRNA conjugates in glioblastoma xenograft tumors in vivo.Nucleic acids research · 2024Article
- Biomaterial-basedCancer pathogenesis and therapy · 2023Review
- Investigation of early molecular alterations in tauopathy with generative adversarial networks.Scientific reports · 2023Article
- The Spectrum of Alzheimer-Type Pathology in Cognitively Normal Individuals.Journal of Alzheimer's disease : JAD · 2023Article
- Exploring the inverse association of glioblastoma multiforme and Alzheimer's disease via bioinformatics analysis.Medical oncology (Northwood, London, England) · 2022Article
- BrainBase: a curated knowledgebase for brain diseases.Nucleic acids research · 2022Article
- Temporal Cortex Microarray Analysis Revealed Impaired Ribosomal Biogenesis and Hyperactivity of the Glutamatergic System: An Early Signature of Asymptomatic Alzheimer's Disease.Frontiers in neuroscience · 2022Article
- MicroRNA-Target Interaction Regulatory Network in Alzheimer's Disease.Journal of personalized medicine · 2021Article
- Investigating the association between cancer and the risk of dementia: Results from the Memento cohort.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021Article
- OCIAD1 contributes to neurodegeneration in Alzheimer's disease by inducing mitochondria dysfunction, neuronal vulnerability and synaptic damages.EBioMedicine · 2020Article
- Biological Hallmarks of Cancer in Alzheimer's Disease.Molecular neurobiology · 2019Review
- The analysis of miRNA expression profiling datasets reveals inverse microRNA patterns in glioblastoma and Alzheimer's disease.Oncology reports · 2019Article
- Novel Functions of the Neurodegenerative-Related Gene Tau in Cancer.Frontiers in aging neuroscience · 2019Article
- The Rules of Engagement: Do Microglia Seal the Fate in the Inverse Relation of Glioma and Alzheimer's Disease?Frontiers in cellular neuroscience · 2019Review
- Glioma and Alzheimer's Disease.Journal of Alzheimer's disease reports · 2018Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Convincing epidemiological data suggest an inverse association between cancer and neurodegeneration, including Alzheimer's disease (AD). Since both AD and cancer are characterized by abnormal, but opposing cellular behavior, i.e., increased cell death in AD while excessive cell growth occurs in cancer, this motivates us to initiate the study into unraveling the shared genes and cell signaling pathways linking AD and glioblastoma multiform (GBM). In this study, a comprehensive bioinformatics analysis on clinical microarray datasets of 1,091 GBM and 524 AD cohorts was performed. Significant genes and pathways were identified from the bioinformatics analyses - in particular ERK/MAPK signaling, up-regulated in GBM and Angiopoietin Signaling pathway, reciprocally up-regulated in AD - connecting GBM and AD (P < 0.001), were investigated in details for their roles in GBM growth in an AD environment. Our results showed that suppression of GBM growth in an AD background was mediated by the ERK-AKT-p21-cell cycle pathway and anti-angiogenesis pathway.
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Registered trials
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