Evidence map›Paper›PMID 24322668›Full record

ReviewPediatric surgery international2014

Pediatric thymomas: report of two cases and comprehensive review of the literature.

Annabelle L Fonseca, Doruk E Ozgediz, Emily R Christison-Lagay, Frank C Detterbeck, Michael G Caty

Abstract readCase ReportsReview
PubMed Publisher
In one paragraph

Review in Pediatric surgery international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Mediastinal lesions in children.World journal of clinical cases · 2023
    Review
  3. Pediatric Thymoma: A Review and Update of the Literature.Diagnostics (Basel, Switzerland) · 2022
    Review
  4. Thymic Tumours in Children.Pediatric reports · 2021
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Surveillance after pediatric thymoma resection.Mediastinum (Hong Kong, China) · 2019
    Article
  10. Thymomas in children.Mediastinum (Hong Kong, China) · 2019
    Article
  11. Review
  12. Imaging of the pediatric thymus: Clinicoradiologic approach.World journal of clinical pediatrics · 2017
    Review
  13. Article
  14. CHEST PAIN DUE TO A GIANT THYMOMA IN AN ADOLESCENT BOY.Acta endocrinologica (Bucharest, Romania : 2005)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Annabelle L FonsecaDepartment of Pediatric Surgery, Yale School of Medicine, FMB 107, 333 Cedar Street, New Haven, CT, 06511, USA, annabelle.fonseca@yale.edu.
Doruk E Ozgediz
Emily R Christison-Lagay
Frank C Detterbeck
Michael G Caty

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThymomas are rare pediatric malignancies with indolent behavior. There are fewer than 50 reported cases and no comprehensive review. We sought to evaluate our recent experience with pediatric thymomas, and comprehensively review the extant literature.

methodsA systematic search of the PubMed database was performed using keywords: "thymoma", "pediatric", "juvenile", "childhood", and "child". Additional studies were identified by a manual search of the reference list.

resultsWe report two patients with thymomas. We identified 22 case reports or series that described 48 patients; 62 % were male, 15 % presented with myasthenia gravis. Fifty percent were Masaoka Stage I, 15 % were Stage II, 13 % were Stage III, and 23 % were Stage IV. Four patients with early stage (I or II) disease were treated with adjuvant therapies in addition to surgical excision, while five patients with late stage (III or IV) disease treated with surgical excision alone. Of studies reporting at least 2-year follow-up, survival was 71 %.

conclusionPediatric thymomas are rare tumors with a slight male predominance. Wide variations were observed in the treatment of thymomas across all stages. Our review indicates a need for large database and multi-institutional studies to clearly elucidate clinical course, prognostic factors and outcome.

Indexed as

AdolescentChildChild, PreschoolCombined Modality TherapyDisease-Free SurvivalFemaleFollow-Up StudiesHumansInfantMaleNeoplasm StagingThymomaThymus NeoplasmsTreatment Outcome

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.