ArticleScientific reports2013
Maternal high-fat diet induces hyperproliferation and alters Pten/Akt signaling in prostates of offspring.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Could GSTP1, PTEN and NKX3.1 gene expression be novel markers in the relationship between prostate cancer and epigenetics?BMC cancer · 2025Article
- Maternal obesity and the impact of associated early-life inflammation on long-term health of offspring.Frontiers in cellular and infection microbiology · 2022Review
- Article
- INPP4B protects from metabolic syndrome and associated disorders.Communications biology · 2021Article
- Diet-Induced Metabolic Dysregulation in Female Mice Causes Osteopenia in Adult Offspring.Journal of the Endocrine Society · 2020Article
- PTEN: A Thrifty Gene That Causes Disease in Times of Plenty?Frontiers in nutrition · 2020Article
- Deletion of inositol polyphosphate 4-phosphatase type-II B affects spermatogenesis in mice.PloS one · 2020Article
- Higher baseline dietary fat and fatty acid intake is associated with increased risk of incident prostate cancer in the SABOR study.Prostate cancer and prostatic diseases · 2019Article
- Maternal obesogenic diet induces endometrial hyperplasia, an early hallmark of endometrial cancer, in a diethylstilbestrol mouse model.PloS one · 2018Article
- Exposure to maternal obesogenic diet worsens some but not all pre-cancer phenotypes in a murine genetic model of prostate cancer.PloS one · 2017Article
- Parental High-Fat Diet Promotes Inflammatory and Senescence-Related Changes in Prostate.Oxidative medicine and cellular longevity · 2017Article
- Bardoxolone Methyl Prevents High-Fat Diet-Induced Colon Inflammation in Mice.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2016Article
- Maternal Obesity, Cage Density, and Age Contribute to Prostate Hyperplasia in Mice.Reproductive sciences (Thousand Oaks, Calif.) · 2016Article
- Effects of obesity on hormonally driven cancer in women.Science translational medicine · 2016Review
- Long-Lasting Consequences of Testosterone Exposure.Endocrinology · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
Developing recommendations for prostate cancer prevention requires identification of modifiable risk factors. Maternal exposure to high-fat diet (HFD) initiates a broad array of second-generation adult disorders in murine models and humans. Here, we investigate whether maternal HFD in mice affects incidence of prostate hyperplasia in offspring. Using three independent assays, we demonstrate that maternal HFD is sufficient to initiate prostate hyperproliferation in adult male offspring. HFD-exposed prostate tissues do not increase in size, but instead concomitantly up-regulate apoptosis. Maternal HFD-induced phenotypes are focally present in young adult subjects and greatly exacerbated in aged subjects. HFD-exposed prostate tissues additionally exhibit increased levels of activated Akt and deactivated Pten. Taken together, we conclude that maternal HFD diet is a candidate modifiable risk factor for prostate cancer initiation in later life.
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