ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2014
Prospective investigation of anterior pituitary function in the acute phase and 12 months after pediatric traumatic brain injury.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 30 citations in OpenAlex.
- Endocrine Dysfunctions After Pediatric Traumatic Brain Injury: Present Insights and Future Directions.Children (Basel, Switzerland) · 2025Review
- New diagnostic approach to central hypothyroidism after traumatic brain injury in children and adolescents.European thyroid journal · 2025Article
- Acute neuroendocrine changes after traumatic brain injury.Brain & spine · 2024Review
- Neuroendocrine Disruptions Following Head Injury.Current neurology and neuroscience reports · 2023Review
- An Approach to Traumatic Brain Injury-Related Hypopituitarism: Overcoming the Pediatric Challenges.Diagnostics (Basel, Switzerland) · 2023Article
- Revisiting peak serum cortisol response to insulin-induced hypoglycemia in children.Journal of endocrinological investigation · 2021Article
- Review
- Traumatic brain injury induced neuroendocrine changes: acute hormonal changes of anterior pituitary function.Pituitary · 2019Review
- Should We Assess Pituitary Function in Children After a Mild Traumatic Brain Injury? A Prospective Study.Frontiers in endocrinology · 2019Article
- Central adrenal insufficiency following traumatic brain injury: a missed diagnosis in the critically injured.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2017Article
- Neuroprotective measures in children with traumatic brain injury.World journal of critical care medicine · 2016Review
- Hypothalamic-Pituitary Autoimmunity and Traumatic Brain Injury.Journal of clinical medicine · 2015Review
- Neuroendocrine Disturbances after Brain Damage: An Important and Often Undiagnosed Disorder.Journal of clinical medicine · 2015Review
- Evaluation of pituitary function in cases with the diagnosis of pediatric mild traumatic brain injury: Cross-sectional study.Journal of neurosciences in rural practiceArticle
- Pituitary and/or hypothalamic dysfunction following moderate to severe traumatic brain injury: Current perspectives.Indian journal of endocrinology and metabolismReview
- Anterior Pituitary Hormonal Disturbances in Patients Suffering with Traumatic Brain Injury.Journal of neurosciences in rural practiceArticle
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAlthough head trauma is common in childhood, there is no enough prospective study investigating both acute phase and 12 months after injury. Therefore, a prospective clinical trial was planned to evaluate the pituitary function in childhood in the acute and chronic phase after traumatic brain injury (TBI).
methodsForty-one children (27 boys and 14 girls, mean age 7 ± 4.3), who were admitted to neurosurgery intensive care unit due to head trauma, were included. Twenty-one (51.2 %) patients had mild, 10 (24.4 %) had moderate, and 10 (24.4 %) had severe TBI. Twenty-two of them were reevaluated 12 months after TBI. Basal pituitary hormone levels were measured during acute (first 24 h) and chronic phase of TBI. Additionally, in the chronic phase, GHRH-arginine test was used for the diagnosis of growth hormone (GH) deficiency.
resultsIn the acute phase, 10 patients (24.4 %) had ACTH deficiency, and the overall 44.3 % of patients had at least one pituitary hormone dysfunction. All the pituitary hormone deficiencies during the acute phase were recovered after 12 months. Two patients (9.1 %) had new-onset GH deficiency in the chronic phase, and in one of them, ACTH deficiency was also present.
conclusionsPresent prospective data clearly demonstrated that most of the hormonal changes in the early acute phase were transient, suggesting an adaptive response, and these changes did not predict the hormone deficiencies after 1 year. In the chronic phase, although GH deficiency was present, the frequency of TBI-induced hypopituitarism was clearly lower than the adult patients.
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