ReviewPediatric nephrology (Berlin, Germany)2014
Controversies on the origin of proliferating epithelial cells after kidney injury.
Review in Pediatric nephrology (Berlin, Germany), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 37 citations in OpenAlex.
- Species, cell proliferation state and oxygen partial pressure are major factors in the in vitro toxicity of repurposed potential ADPKD drugs in human and murine renal proximal tubule cells.Archives of toxicology · 2026Article
- Lineage tracing reveals KSPFrontiers in cell and developmental biology · 2026Article
- Renal tubular epithelial cells response to injury in acute kidney injury.EBioMedicine · 2024Review
- Article
- HNF1A binds and regulates the expression of SLC51B to facilitate the uptake of estrone sulfate in human renal proximal tubule epithelial cells.Cell death & disease · 2023Article
- The Genomic Response to TGF-β1 Dictates Failed Repair and Progression of Fibrotic Disease in the Obstructed Kidney.Frontiers in cell and developmental biology · 2021Review
- Kidney Organoids and Tubuloids.Cells · 2020Review
- Towards adulthood with a solitary kidney.Pediatric nephrology (Berlin, Germany) · 2019Review
- Characterization and determination of cadmium resistance of CD133Toxicology and applied pharmacology · 2019Article
- Organoids as a new model for improving regenerative medicine and cancer personalized therapy in renal diseases.Cell death & disease · 2019Article
- Persistent and inducible neogenesis repopulates progenitor renin lineage cells in the kidney.Kidney international · 2017Article
- Comparing adult renal stem cell identification, characterization and applications.Journal of biomedical science · 2017Review
- Cellular plasticity in kidney injury and repair.Nature reviews. Nephrology · 2017Review
- Autophagy, Innate Immunity and Tissue Repair in Acute Kidney Injury.International journal of molecular sciences · 2016Review
- Species diversity regarding the presence of proximal tubular progenitor cells of the kidney.European journal of histochemistry : EJH · 2016Article
- Sox9-Positive Progenitor Cells Play a Key Role in Renal Tubule Epithelial Regeneration in Mice.Cell reports · 2016Article
- Therapeutic use of human renal progenitor cells for kidney regeneration.Nature reviews. Nephrology · 2015Review
- Development and application of human adult stem or progenitor cell organoids.Nature reviews. Nephrology · 2015Review
- Who regenerates the kidney tubule?Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2015Review
- Kidney Regeneration: Lessons from Development.Current pathobiology reports · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The kidney possesses the capacity to repair after an acute insult, even one that causes complete organ failure. This regenerative response is characterized by robust proliferation of epithelial cells, principally those located in the proximal tubule. Because defining the origin of these reparative cells has important consequences for stem cell and regenerative approaches to treating kidney injury, this area has been the subject of intense investigation and debate. While progress has been made in narrowing the possible origin of these cells to an intratubular source, there has been no consensus between the possibility of a pre-existing intratubular stem or progenitor cell versus the possibility that fully differentiated epithelial cells re-enter the cell cycle after injury and generate new proximal tubule cells through self-duplication. This review will summarize the evidence on both sides of this active controversy and provide support for the notion that no pre-existing proximal tubule stem cell population exists, but rather all differentiated proximal tubule epithelia have the capacity to proliferate during repair by a mechanism of dedifferentiation and self-duplication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.