Evidence map›Paper›PMID 24322588›Full record

ReviewAnesthesiology2014

Mechanisms of acupuncture-electroacupuncture on persistent pain.

Ruixin Zhang, Lixing Lao, Ke Ren, Brian M Berman

5 registry-linked trialsOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Anesthesiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 440 papers, 23 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
440citing papers in PubMed, 23 pooled it
51.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02232282 nacompletednot on this map

Acupuncture for Female Interstitial Cystitis/Painful Bladder Syndrome and Its Effect on the Urinary Microbiome: A Randomized Controlled Trial

TypeinterventionalSponsorLoyola UniversityRan2014 to 2017Enrolled22ConditionsPainful Bladder Syndrome, Interstitial CystitisArmsstandard acupuncture treatment, Control Sham/Minimal Acupuncture
NCT03580317 nacompletednot on this mapstarted 2018, after this paper: background citation

Electroacupuncture Therapy for Change of Pain in Classical Trigeminal Neuralgia

TypeinterventionalSponsorZhejiang Chinese Medical UniversityRan2018 to 2021Enrolled120ConditionsTrigeminal NeuralgiaArmsEA+ Carbamazepine, EA+Placebo, sham EA+Carbamazepine, sham EA+Placebo
NCT03854188 nawithdrawnnot on this mapstarted 2021, after this paper: background citation

Acupuncture for Relieving Chronic Pelvic Pain

TypeinterventionalSponsorWilliam Xu, MDRan2021 to 2021Enrolled0ConditionsPelvic PainArmsAcupuncture
NCT06054087 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Effectiveness of Electroacupuncture in the Treatment of Diabetic Peripheral Neuropathy: a MulticentreRandomised Controlled Trial

TypeinterventionalSponsorZhejiang Chinese Medical UniversityRan2023 to 2025Enrolled104ConditionsDiabetic Peripheral Neuropathic PainArmsBasal therapy+EA, Basal therapy
NCT06074913 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Early Warning of Diabetic Peripheral Neuropathy by Using Infrared Thermography and the Effectiveness of Electroacupuncture in Its Prevention

TypeinterventionalSponsorZhejiang Chinese Medical UniversityRan2023 to 2025Enrolled200ConditionsDiabetic Peripheral NeuropathyArmsinfrared thermography (IRT), Basal therapy+EA, Basal therapy
3 · Its place in the literature

Who cites it

440 citing papers in PubMed, 23 syntheses or guidelines pooled it, 860 citations in OpenAlex.

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380 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Ruixin ZhangFrom the Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, Maryland (R.Z., L.L., and B.M.B.); and Department of Neural and Pain Sciences, Dental School, University of Maryland, Baltimore, Maryland (K.R.).
Lixing Lao
Ke Ren
Brian M Berman
University of Maryland, Baltimore · US

Funding

Scientific Analysis CoreP01AT002605 · NCCIH · UNIVERSITY OF MARYLAND BALTIMORE · PI BERMAN, BRIAN M · 2005 to 2009
$6.4M
Effects of acupuncture on pain-induced affective responseR21AT005474 · NCCIH · UNIVERSITY OF MARYLAND BALTIMORE · PI ZHANG, RUIXIN · 2010 to 2011
$411k
NCCIH NIH HHS P01 AT002605NCCIH NIH HHS P01AT002605NCCIH NIH HHS R21 AT005474NCCIH NIH HHS R21AT005474
6 · The paper itself

Abstract

In the last decade, preclinical investigations of electroacupuncture mechanisms on persistent tissue injury (inflammatory), nerve injury (neuropathic), cancer, and visceral pain have increased. These studies show that electroacupuncture activates the nervous system differently in health than in pain conditions, alleviates both sensory and affective inflammatory pain, and inhibits inflammatory and neuropathic pain more effectively at 2 to 10 Hz than at 100 Hz. Electroacupuncture blocks pain by activating a variety of bioactive chemicals through peripheral, spinal, and supraspinal mechanisms. These include opioids, which desensitize peripheral nociceptors and reduce proinflammatory cytokines peripherally and in the spinal cord, and serotonin and norepinephrine, which decrease spinal N-methyl-D-aspartate receptor subunit GluN1 phosphorylation. Additional studies suggest that electroacupuncture, when combined with low dosages of conventional analgesics, provides effective pain management which can forestall the side effects of often-debilitating pharmaceuticals.

Indexed as

Acupuncture PointsAcupuncture TherapyAnimalsChronic PainDisease Models, AnimalElectroacupunctureHumansInflammationNeoplasmsNeuralgiaSensationSpinal CordVisceral Pain

Identifiers

PMID24322588
PMCPMC3947586
OpenAlexW2070309248

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.