ArticleJournal of virological methods2014
Identification of vaccine-derived polioviruses using dual-stage real-time RT-PCR.
Article in Journal of virological methods, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 44 citations in OpenAlex.
- Tracking poliovirus through wastewater: environmental surveillance insights from Haïti (2020-2023).Applied and environmental microbiology · 2025Article
- Recent emergence of vaccine-derived poliovirus type 2 in Senegal and virus spread to neighboring countries.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2025Article
- A review on health system-based surveillance for acute flaccid paralysis: technological advancements, challenges, and outlooks.Journal of health, population, and nutrition · 2025Review
- Evaluation of Direct Detection Protocols for Poliovirus from Stool Samples of Acute Flaccid Paralysis Patients.Viruses · 2023Article
- The Fight against Poliovirus Is Not Over.Microorganisms · 2023Review
- Inferring Numbers of Wild Poliovirus Excretors Using Quantitative Environmental Surveillance.Vaccines · 2021Article
- Article
- Field Performance of Two Methods for Detection of Poliovirus in Wastewater Samples, Mexico 2016-2017.Food and environmental virology · 2019Article
- Environmental Surveillance of Polioviruses in Armenia, Colombia before Trivalent Oral Polio Vaccine Cessation.Viruses · 2019Article
- Detection and characterization of polioviruses originating from urban sewage in Yaounde and Douala, Cameroon 2016-2017.BMC research notes · 2019Article
- Genetic landscape and macro-evolution of co-circulating Coxsackieviruses A and Vaccine-derived Polioviruses in the Democratic Republic of Congo, 2008-2013.PLoS neglected tropical diseases · 2019Article
- The detection of 3 ambiguous type 2 vaccine-derived polioviruses (VDPV2s) in Uganda.Virology journal · 2018Article
- Diagnostic Assay Development for Poliovirus Eradication.Journal of clinical microbiology · 2018Article
- Emergence of Vaccine-Derived Polioviruses during Ebola Virus Disease Outbreak, Guinea, 2014-2015.Emerging infectious diseases · 2018Article
- Detection of Emerging Vaccine-Related Polioviruses by Deep Sequencing.Journal of clinical microbiology · 2017Article
- The Global Polio Laboratory Network as a Platform for the Viral Vaccine-Preventable and Emerging Diseases Laboratory Networks.The Journal of infectious diseases · 2017Article
- Comparison of ELISA and dual stage real time RT-PCR to differentiate Sabin like and non-Sabin like poliovirus isolates.Virusdisease · 2017Article
- Epidemiological Surveillance of Poliomyelitis During the Military and Political Conflict in the Central African Republic, 2013 and 2014.Open forum infectious diseases · 2017Article
- Sabin Vaccine Reversion in the Field: a Comprehensive Analysis of Sabin-Like Poliovirus Isolates in Nigeria.Journal of virology · 2016Article
- Acute flaccid paralysis surveillance indicators in the Democratic Republic of Congo during 2008-2014.The Pan African medical journal · 2016Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Vaccine-derived polioviruses (VDPVs) are associated with polio outbreaks and prolonged infections in individuals with primary immunodeficiencies. VDPV-specific PCR assays for each of the three Sabin oral poliovirus vaccine (OPV) strains were developed, targeting sequences within the VP1 capsid region that are selected for during replication of OPV in the human intestine. Over 2400 Sabin-related isolates and identified 755 VDPVs were screened. Sensitivity of all assays was 100%, while specificity was 100% for serotypes 1 and 3, and 76% for serotype 2. The assays permit rapid, sensitive identification of OPV-related viruses and flag programmatically important isolates for further characterization by genomic sequencing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.