ArticleBrain research2014
Combined treatment with acupuncture reduces effective dose and alleviates adverse effect of L-dopa by normalizing Parkinson's disease-induced neurochemical imbalance.
Article in Brain research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Does Acupuncture Protect Dopamine Neurons in Parkinson's Disease Rodent Model?: A Systematic Review and Meta-Analysis.Frontiers in aging neuroscience · 2019Pooled it
- Comparative Efficacy of Acupuncture Therapy in Primary Essential Tremor: A Network Meta-Analysis and Systematic Review.Healthcare (Basel, Switzerland) · 2026Review
- Central Role of Hypothalamic Circuits for Acupuncture's Anti-Parkinsonian Effects.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Peripheral mast cells derive the effects of acupuncture in Parkinson's disease.Frontiers in aging neuroscience · 2024Article
- The mechanistic effects of acupuncture in rodent neurodegenerative disease models: a literature review.Frontiers in neuroscience · 2024Review
- Embelin and levodopa combination therapy for improved Parkinson's disease treatment.Translational neuroscience · 2022Article
- Electroacupuncture in treatment of Parkinson disease: A protocol for meta-analysis and systematic review.Medicine · 2021Article
- Acupuncture for Parkinson's Disease: Efficacy Evaluation and Mechanisms in the Dopaminergic Neural Circuit.Neural plasticity · 2021Review
- Acupuncture Alleviates Levodopa-Induced Dyskinesia via Melanin-Concentrating Hormone in Pitx3-Deficient aphakia and 6-Hydroxydopamine-Lesioned Mice.Molecular neurobiology · 2019Article
- Study on Effect of Striatal mGluR2/3 in Alleviating Motor Dysfunction in Rat PD Model Treated by Exercise Therapy.Frontiers in aging neuroscience · 2019Article
- Effects of Combined Treatment with Acupuncture and Chunggan Formula in a Mouse Model of Parkinson's Disease.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Novel Neuroprotective Effects of Melanin-Concentrating Hormone in Parkinson's Disease.Molecular neurobiology · 2017Article
- The Role of Group II Metabotropic Glutamate Receptors in the Striatum in Electroacupuncture Treatment of Parkinsonian Rats.CNS neuroscience & therapeutics · 2017Article
- Therapies for Parkinson's diseases: alternatives to current pharmacological interventions.Journal of neural transmission (Vienna, Austria : 1996) · 2016Review
- Professional ethics in complementary and alternative medicines in management of Parkinson's disease.Journal of Parkinson's disease · 2016Review
- Acupuncture points for treating Parkinson's disease based on animal studies.Chinese journal of integrative medicine · 2016Review
- Acupuncture on GB34 activates the precentral gyrus and prefrontal cortex in Parkinson's disease.BMC complementary and alternative medicine · 2014Article
- Mechanisms for alternative treatments in Parkinson's disease: acupuncture, tai chi, and other treatments.Current neurology and neuroscience reports · 2014Review
- Research advances in treatment of neurological and psychological diseases by acupuncture at the Acupuncture Meridian Science Research Center.Integrative medicine research · 2014Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
This study first showed the behavioural benefits of novel combination therapy of L-dopa with acupuncture on Parkinson's disease, and its underlying mechanisms within basal ganglia. The previous study reported that acupuncture may improve the motor function of a Parkinson's disease (PD) mouse model by increasing the dopamine efflux and turnover ratio of dopamine. Hence, we hypothesised that combining L-dopa with acupuncture would have a behavioural benefit for those with PD. We performed unilateral injections of 6-OHDA into the striatum of C57Bl/6 mice to model hemi-Parkinsonian attributes. To test motor function and dyskinetic anomalies, we examined cylinder behaviour and abnormal involuntary movement (AIM), respectively. We found that (1) a 50% reduced dose of L-dopa (7.5 mg/kg) combined with acupuncture showed an improvement in motor function that was comparable to mice given the standard dose of L-dopa treatment (15 mg/kg) only, and that (2) the combination treatment (L-dopa +acupuncture) was significantly superior in reducing AIM scores when equivalent doses of L-dopa were used. The combination treatment also significantly reduces the abnormal increase of GABA contents in the substantia nigra compared to the standard L-dopa treatment. Furthermore, abnormal expression of FosB, the immediate early gene of L-dopa induced dyskinesia (LID), was mitigated in the striatum by the combination treatment. All of these results indicate that acupuncture enhances the benefits of L-dopa on motor function with reduced dose of L-dopa and alleviating LID by normalising neurochemical imbalance within the basal ganglia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.