Observational studyBMC cardiovascular disorders2013
Red cell distribution width is associated with long-term prognosis in patients with stable coronary artery disease.
Observational study in BMC cardiovascular disorders, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Prognostic value of red cell distribution width in patients undergoing percutaneous coronary intervention: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2026Pooled it
- Prognostic Impact of Red Cell Distribution Width on the Development of Contrast-Induced Nephropathy, Major Adverse Cardiac Events, and Mortality in Coronary Artery Disease Patients Undergoing Percutaneous Coronary Intervention.Current cardiology reviews · 2021Pooled it
- An overall and dose-response meta-analysis of red blood cell distribution width and CVD outcomes.Scientific reports · 2017Pooled it
- Red cell distribution width and common disease onsets in 240,477 healthy volunteers followed for up to 9 years.PloS one · 2018Trial
- Red Cell Distribution Width-Standard Deviation and the Severity of In-Stent Restenosis: Associations with Angiographic Stenosis Burden and Mehran Classification.Medicina (Kaunas, Lithuania) · 2026Observational
- Development and Validation of a Nomogram to Predict Respiratory Failure With Influenza.Immunity, inflammation and disease · 2026Article
- Associations of Red Blood Cell Distribution Width-Derived Indicators and Their Longitudinal Dynamic Trajectories With Mortality Risk in Critically Ill Patients With Pulmonary Hypertension.Pulmonary circulation · 2026Article
- Association of Neutrophil-Lymphocyte Ratio and Red Blood Cell Distribution Width with Poor Outcome in Pediatric Cardiac Surgery - A Retrospective Observational Study.Annals of cardiac anaesthesia · 2024Observational
- Using red blood cell distribution width to predict death after abdominal aortic aneurysm rupture.BMC cardiovascular disorders · 2023Article
- Prognostic Value of the Red Blood Cell Distribution Width-to-Albumin Ratio in Critically Ill Older Patients with Acute Kidney Injury: A Retrospective Database Study.Emergency medicine international · 2023Article
- Bad players in AL amyloidosis in the current era of treatment.Expert review of hematology · 2023Article
- Biomarkers in Pulmonary Arterial Hypertension.Diagnostics (Basel, Switzerland) · 2022Review
- Circulating Blood-Based Biomarkers in Pulmonary Hypertension.Journal of clinical medicine · 2022Review
- Red Blood Cell Distribution Width as Novel Biomarker in Cardiovascular Diseases: A Literature Review.Journal of blood medicine · 2022Review
- Complete Blood Count-Derived Indices as Prognostic Factors of 5-Year Outcomes in Patients With Confirmed Coronary Microvascular Spasm.Frontiers in cardiovascular medicine · 2022Article
- Hemoglobin-to-Red-Cell Distribution Width Ratio Is a Novel Predictor of Long-Term Patient Outcomes After Percutaneous Coronary Intervention: A Retrospective Cohort Study.Frontiers in cardiovascular medicine · 2022Article
- Predictive Value of Red Blood Cell Distribution Width for 1-Year All-Cause Mortality in Critically Ill Patients with Acute Myocardial Infarction.International journal of general medicine · 2022Article
- Predicting mortality rate in elderly patients operated for hip fracture using red blood cell distribution width, neutrophil-to-lymphocyte ratio, and Nottingham Hip Fracture Score.Joint diseases and related surgery · 2022Article
- Higher Red Blood Cell Distribution Width is a Poor Prognostic Factor for Patients with Chronic Myeloid Leukemia.Cancer management and research · 2021Article
- Red Cell Distribution Width Is a Risk Factor for Hip Fracture in Elderly Men Without Anemia.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2020Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundData regarding the association between red cell distribution width (RDW) values and mortality in patients with stable coronary artery disease are scarce. We aimed to investigate the link between mortality and RDW in patients with stable coronary artery disease undergoing percutaneous coronary intervention (PCI).
methodsWe analyzed 2550 consecutive patients with stable coronary artery disease who underwent PCI between 2007 and 2011 at our institution. The patients were divided into four groups according to RDW quartiles. The association between the RDW values and the outcomes was assessed using Cox proportional regression analysis after adjusting for clinical, echocardiographic, hemodynamic and laboratory data in the whole population and in subgroups stratified by gender, presence of diabetes, anemia or heart failure.
resultsIn the entire population, there was a stepwise relationship between RDW intervals and comorbidities. Patients with the highest RDW values were older and more often burdened with diabetes, heart failure and chronic kidney disease. There was an almost 4-fold increase in mortality during an average of 2.5 years of follow-up between the group of patients with RDW values lower than 13.1% (25th percentile) and the group with RDW values higher than 14.1% (75th percentile), (4.3% vs. 17.1%, p < 0.0001). After adjusting for the covariates, RDW remained significantly associated with mortality in the whole cohort (HR-1.23 [95% CI (1.13-1.35), p < 0.0001]) and in the subgroups stratified by gender, age (over and under 75 years), presence of anemia, diabetes, heart failure and chronic kidney disease.
conclusionHigher RDW values correspond to higher comorbidity burdens and higher mortality. RDW is an independent predictor of mortality in patients with stable coronary artery disease.
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