ReviewPeriodontology 20002014
Role of chronic stress and depression in periodontal diseases.
Review in Periodontology 2000, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
70 citing papers in PubMed, 3 syntheses or guidelines pooled it, 156 citations in OpenAlex.
- Interplay of depressive symptoms and clinical oral health conditions: a systematic review and meta-analysis.Brazilian oral research · 2026Pooled it
- The Influence of Psychological Stress and Stress-Related Disorders in the Treatment Outcome of Periodontitis: A Systematic Review and Meta-Analysis.Journal of clinical periodontology · 2025Pooled it
- Influence of Inflammation, Gut Microbiota, and Stress on Cognition and Oral Health Therapies.Current Alzheimer research · 2025Pooled it
- Comparative Analysis of Subgingival Microbial Profiles in Patients with Periodontal Disease with and Without Depressive Comorbidity.Journal of clinical medicine · 2026Article
- Article
- Evaluation of Osteoprotegerin (OPG) and Receptor Activator of Nuclear Factor Kappa-B Ligand (RANKL) Biomarker Concentrations in the Saliva of Patients with Periodontitis and Depression.Clinical and experimental dental research · 2026Article
- Association between periodontal disease and intrinsic capacity in older adults: insights from NHANES 2009-2014.GeroScience · 2026Article
- Dysregulation of Oral Microbial Eicosapentaenoic Acid Induced by Chronic Restraint Stress Exacerbates Periodontitis via M1 Macrophage Polarization.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Psychological distress, work burden, and oral health-related quality of life among schoolteachers in Saudi Arabia.BMC oral health · 2026Article
- Comparing the effectiveness of yoga with supervised tooth brushing on oral health maintenance among adolescents of Irular tribes: A cluster randomized trial.Journal of family medicine and primary care · 2026Article
- IL-15, IL-18 and IL-21 Along the Stress-Smoking-Periodontal Health Axis: A Cross-Sectional Study in Mexican Adults.Biomedicines · 2026Article
- Periodontal disease and endocrine imbalance: a molecular pathways perspective.Frontiers in dental medicine · 2026Review
- The oral - X axis: from periodontal dysbiosis to systemic disease.Frontiers in immunology · 2026Review
- Brain Structures, Circuits, and Networks Involved in Immune Regulation, Periodontal Health, and Disease.Life (Basel, Switzerland) · 2025Review
- Evidence for the association between psychological stress and peri-implant health among middle-aged and elderly adults: A systemic review.World journal of clinical cases · 2025Article
- Psychological Stress Reduces the Effectiveness of Periodontal Treatment: A Systematic Review.Journal of clinical medicine · 2025Review
- Sex effects on early life features of the gingival transcriptome.Frontiers in dental medicine · 2025Article
- Interdisciplinary research on periodontitis and depression: a bibliometric analysis of research trends, hotspots and future directions.Frontiers in oral health · 2025Article
- Effect of sleep deprivation and stress on periodontal disease: A clinico-biochemical Study.Bioinformation · 2025Article
- Mitochondrial Dysfunction in Diabetic Periodontitis: Mechanisms and Therapeutic Potential.Journal of inflammation research · 2025Review
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An extensive body of experimental and clinical evidence documents the negative impact of chronic psychological stress and depression on the immune system and health. Chronic stress and depression can result in general dysregulation of the immune system, of both cellular and humoral pathways, which may contribute to pathogenic infection and concomitant periodontal tissue destruction. In general, the evidence is consistent with the hypothesis that stress can modify the host defense and progression of periodontal infections in patients susceptible to periodontitis. However, substantial evidence also indicates that these conditions can mediate risk for disease, including periodontitis, through changes in health-related behaviors, such as oral hygiene, smoking and diet. The unequivocal interpretation of studies has also been hampered, in part, by issues related to conceptualization of stress and depression, as well as commonly associated comorbidities, such as diabetes, that can modify the onset and progression of periodontal disease. In addition, stress and depression appear to fall into a spectrum, ranging from mild to severe, involving a complex interaction of genetic background, coping strategies and environment. Differences in the conceptualization of stress and depression are probably important in assessing associations with other biologic and clinical measures. Future studies are necessary to clarify the complex interactions of chronic stress and depression in periodontal diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.