ReviewPeriodontology 20002014
Inflammatory and immune pathways in the pathogenesis of periodontal disease.
Review in Periodontology 2000, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 655 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of Some Different Photosensitizers in Photodynamic Inactivation of Periodontal Pathogens:A Randomized Clinical Trial
Investigation of the Relationships and Clinical Parameters Between IL-6, IL-17 and IL-35 Levels in the Gingival Crevicular Fluid of Individuals With Grade B-C Stage III-IV Periodontitis
Lepidium Sativum Extract Versus Simvastatin as an Adjunctive Local Delivery Agents to Non-Surgical Periodontal Therapy: A Randomized Controlled Clinical Trial With Biochemical Analysis
Who cites it
655 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Contribution of Resveratrol on Periodontal Disease Control and Treatment: A Systematic Review.Oral health & preventive dentistry · 2026Pooled it
- Immunomodulation as a novel treatment strategy for periodontal disease: a systematic review.BMC oral health · 2026Pooled it
- Association between overweight/obesity and oral health in adults aged 55 and older: a systematic review and meta-analysis.GeroScience · 2026Pooled it
- Investigating the Association Between Oral Hygiene and Oral Cancer: A Systematic Review and Meta-Analysis.Oral diseases · 2026Pooled it
- Clinical effect of immunomodulatory therapy in periodontitis: a systematic review and meta-analysis.Frontiers in bioengineering and biotechnology · 2025Pooled it
- Association between periodontal disease and Alzheimer's disease: umbrella review.Frontiers in dental medicine · 2025Pooled it
- Effect of Er: YAG laser therapy in non-surgical periodontal treatment: an umbrella review.BMC oral health · 2024Pooled it
- Immunomodulatory effects of high versus low intensity diode laser as adjunct to non-surgical periodontal therapy in periodontitis.BMC research notes · 2026Trial
- Comparative evaluation of demineralized freeze-dried bone allograft with and without doxycycline hyclate loaded proniosomal gel in the treatment of class II furcation defects: a randomized controlled trial.Clinical oral investigations · 2025Trial
- Adjunctive therapea - a promising method in the treatment of periodontal disease.Clinical oral investigations · 2025Trial
- Effect of initial periodontal therapy on metallothionein levels in smokers and non-smokers with periodontitis.Odontology · 2024Trial
- Shotgun Metagenomic Analysis Reveals Taxonomic and Functional Transitions in the Salivary Microbiome During Periodontal Disease Progression.Journal of clinical periodontology · 2026Observational
- Dicer-independent miR-451a is upregulated in periodontitis and potentiates inflammation by impairing macrophage polarization and SOCS activity.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- The dynamic landscape of T helper cell plasticity and Th17-Treg instability in periodontitis.Experimental & molecular medicine · 2026Review
- Oral Piercing in the Aspect of Periodontal and Dental Health-A Narrative Review.Journal of clinical medicine · 2026Review
- Sleep duration and oral functional impairment: potential involvement of monocyte-related inflammation.Odontology · 2026Article
- Total Water Intake and Periodontitis in Korean Adults: Evidence from a Nationally Representative Survey.Oral health & preventive dentistry · 2026Article
- Article
- Integrated AI-Driven Discovery of MAPK3 Inhibitors for Oral Inflammatory and Proliferative Diseases.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Article
595 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The pathogenesis of periodontitis involves a complex immune/inflammatory cascade that is initiated by the bacteria of the oral biofilm that forms naturally on the teeth. The susceptibility to periodontitis appears to be determined by the host response; specifically, the magnitude of the inflammatory response and the differential activation of immune pathways. The purpose of this review was to delineate our current knowledge of the host response in periodontitis. The role of innate immunity, the failure of acute inflammation to resolve (thus becoming chronic), the cytokine pathways that regulate the activation of acquired immunity and the cells and products of the immune system are considered. New information relating to regulation of both inflammation and the immune response will be reviewed in the context of susceptibility to, and perhaps control of, periodontitis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.