Evidence map›Paper›PMID 24320761›Full record

ArticleJournal of the American Geriatrics Society2013

Relationship between persistent pain and 5-year mortality: a population-based prospective cohort study.

Joseph W Shega, Melissa Andrew, Ashwin Kotwal, Denys T Lau, Keela Herr, Mary Ersek, Debra K Weiner, Marshall H Chin, William Dale

Abstract read
In one paragraph

Article in Journal of the American Geriatrics Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. From age to frailty: redefining chronic pain characterization.Aging clinical and experimental research · 2025
    Article
  3. Article
  4. Patient-reported pain severity is associated with shorter survival in older adults with newly diagnosed cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  5. Multi-dimensional frailty and Oral Health-Related Quality-of-Life in older adults: a cross-sectional study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
    Observational
  6. Article
  7. Article
  8. Article
  9. Linking Persistent Pain and Frailty in Older Adults.Pain medicine (Malden, Mass.) · 2020
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Incorporating Persistent Pain in Phenotypic Frailty Measurement and Prediction of Adverse Health Outcomes.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017
    Article
  15. Article
  16. Pain in the Elderly.Current pain and headache reports · 2016
    Review
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Joseph W ShegaSection of Geriatrics and Palliative Medicine, University of Chicago, Chicago, Illinois.
Melissa AndrewDivision of Geriatric Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
Ashwin KotwalSection of Geriatrics and Palliative Medicine, University of Chicago, Chicago, Illinois.
Denys T LauDivision of Health Care Statistics, National Center for Health Statistics, Centers for Disease Control and Prevention, Atlanta, Georgia.
Keela HerrCollege of Nursing, University of Iowa, Iowa City, Iowa.
Mary ErsekSchool of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania.
Debra K WeinerGeriatric Research, Education and Clinical Center, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennslvania.
Marshall H ChinSection of General Internal Medicine, University of Chicago, Chicago, Illinois.
William DaleSection of Geriatrics and Palliative Medicine, University of Chicago, Chicago, Illinois.

Funding

Research Design, Data, and Analytics CoreP30DK092949 · NIDDK · UNIVERSITY OF CHICAGO · PI Ronald T. Ackermann, MARSHALL H CHIN · 2011 to 2026
$10.0M
Research and Mentorship in Improving Diabetes CareK24DK071933 · NIDDK · UNIVERSITY OF CHICAGO · PI CHIN, MARSHALL H · 2005 to 2014
$1.6M
Non-cancer pain and cognitive impairment: A disabling relationshipK23AG029815 · NIA · UNIVERSITY OF CHICAGO · PI SHEGA, JOSEPH W · 2008 to 2012
$762k
Caregiving Skills in Effective Medication Management for Hospice PatientsK01AG027295 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LAU, DENYS · 2007 to 2011
$611k
CIHR MOP-62823NIA NIH HHS K01 AG027295NIA NIH HHS K23 AG029815NIA NIH HHS K23AG029815NIDDK NIH HHS K24 DK071933NIDDK NIH HHS P30 DK092949
6 · The paper itself

Abstract

objectivesTo assess the association between self-reported noncancer pain and 5-year mortality.

designCohort.

settingCommunity-dwelling older adults.

participantsCanadian Study of Health and Aging 1996 wave. MEASUREMENTS: Registrar of Vital Statistics-established 5-year mortality. Noncancer pain was assessed using the 5-point verbal descriptor scale, dichotomized into no or very mild versus moderate, severe, or very severe pain. Frailty was the accumulation of health deficits. Cognitive status (Modified Mini-Mental State Examination) and depressed mood (five-item mental health screening questionnaire) were also assessed. Multivariable logistic regression and Cox proportional hazards were used to analyze the relationship between pain and 5-year mortality.

resultsOf 5,703 participants, 4,694 (82.3%) had complete data for analysis; 1,663 of these (35.4%) reported moderate, severe, or very severe pain, and 1,343 (28.6%) had died at 5-year follow-up. Four hundred ninety-six of those who died (29.8%) reported moderate, severe, or very severe pain and 847 (27.9%) no or very mild pain. Multivariate logistic analysis found that individuals with moderate, severe, or very severe pain had lower odds of 5-year mortality than those with no or very mild pain (odds ratio=0.78, 95% confidence interval (CI)=0.66-0.92; P<.001). The risk of death was lower in persons reporting moderate or greater pain than in those with no or very mild pain (HR=0.85, 95% CI=0.75-0.96; P=.01). An interaction between pain and sex explained this effect. Men with pain were not significantly more likely than men without pain to die (HR=1.00, 95% CI=0.84-1.19; P=.99), whereas women without pain (HR=0.54, 95% CI=0.47-0.63; P<0.01) and women with pain (HR=0.40; CI=0.33-0.47; P<.01) had less risk of death than men without and with pain, respectively.

conclusionOlder women with pain were less likely to die within 5 years than older women without pain, men in pain, or men without pain.

Indexed as

AgedAged, 80 and overCanadaComorbidityConfounding Factors, EpidemiologicFemaleFrail ElderlyGeriatric AssessmentHumansMalePainPain MeasurementProspective StudiesRisk FactorsSurveys and Questionnairesmortalityolder adultpain

Identifiers

PMID24320761
PMCPMC4140782

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.