ArticleThe Journal of cell biology1986
Reactivated melanophore motility: differential regulation and nucleotide requirements of bidirectional pigment granule transport.
Article in The Journal of cell biology, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 80 citations in OpenAlex.
- Enzymatic, morphological, and genotoxic effects of benzo[a]pyrene in rainbow trout (Oncorhynchus mykiss).Environmental science and pollution research international · 2021Article
- Biochemical regulation of pigment motility in vertebrate chromatophores: a review of physiological color change mechanisms.Current zoology · 2016Article
- Single-molecule fluorescence and in vivo optical traps: how multiple dyneins and kinesins interact.Chemical reviews · 2014Review
- Activation of muscarinic acetylcholine receptors elicits pigment granule dispersion in retinal pigment epithelium isolated from bluegill.BMC neuroscience · 2004Article
- Regulated bidirectional motility of melanophore pigment granules along microtubules in vitro.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Intracellular calcium and cAMP regulate directional pigment movements in teleost erythrophores.The Journal of cell biology · 1994Article
- Characterization of a serotonin receptor endogenous to frog melanophores.Naunyn-Schmiedeberg's archives of pharmacology · 1994Article
- GTP gamma S inhibits organelle transport along axonal microtubules.The Journal of cell biology · 1993Article
- Protein kinase C activation antagonizes melatonin-induced pigment aggregation in Xenopus laevis melanophores.The Journal of cell biology · 1992Article
- Kinesin is responsible for centrifugal movement of pigment granules in melanophores.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Nucleotide specificities of anterograde and retrograde organelle transport in Reticulomyxa are indistinguishable.The Journal of cell biology · 1991Article
- Regulation of organelle transport in melanophores by calcineurin.The Journal of cell biology · 1990Article
- Incorporation of Paramecium axonemal tubulin into higher plant cells reveals functional sites of microtubule assembly.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
- The use of permeabilized cells to study the ion requirements of receptor-ligand dissociation in endosomes.The Biochemical journal · 1989Article
- Changes in lysosome shape and distribution correlated with changes in cytoplasmic pH.The Journal of cell biology · 1989Article
- Calcium regulation of pigment transport in vitro.The Journal of cell biology · 1988Article
- On the mechanism of anaphase A: evidence that ATP is needed for microtubule disassembly and not generation of polewards force.The Journal of cell biology · 1987Article
- Direction of force generated by the inner row of dynein arms on flagellar microtubules.The Journal of cell biology · 1987Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
To study the molecular basis for organized pigment granule transport, procedures were developed to lyse melanophores of Tilapia mossambica under conditions in which pigment granule movements could be reactivated. Gentle lysis of the melanophores resulted in a permeabilized cell model, which, in the absence of exogenous ATP, could undergo multiple rounds of pigment granule aggregation and dispersion when sequentially challenged with epinephrine and cAMP. Both directions of transport required ATP, since aggregation or dispersion in melanophores depleted of nucleotides could be reactivated only upon addition of MgATP or MgATP plus cAMP, respectively. Differences between the nucleotide sensitivities for aggregation and dispersion were demonstrated by observations that aggregation had a lower apparent Km for ATP than did dispersion and could be initiated at a lower ATP concentration. Moreover, aggregation could be initiated by ADP, but only dispersion could be reactivated by the thiophosphate ATP analog, ATP gamma S. The direction of pigment transport was determined solely by cAMP, since pigment granules undergoing dispersion reaggregated when cAMP was removed, and those undergoing aggregation dispersed when cAMP was added. These results provide evidence that pigment granule motility may be based on two distinct mechanisms that are differentially activated and regulated to produce bidirectional movements.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.