ArticleAIDS patient care and STDs2013
Early warning indicators for first-line virologic failure independent of adherence measures in a South African urban clinic.
Article in AIDS patient care and STDs, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03438370 (Outcomes of Differentiated Models of Antiretroviral Treatment), which is not on this map. Cited by 34 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Outcomes of Differentiated Models of Antiretroviral Treatment (ART) Provision: Multi-Month Dispensing (MMD) of ART in Community ART Distribution for Stable HIV Infected Patients
Who cites it
34 citing papers in PubMed, 4 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Exploring linkages between drought and HIV treatment adherence in Africa: a systematic review.The Lancet. Planetary health · 2022Pooled it
- Burden of Depression in Outpatient HIV-Infected adults in Sub-Saharan Africa; Systematic Review and Meta-analysis.AIDS and behavior · 2020Pooled it
- Associations Between Anxiety and Adherence to Antiretroviral Medications in Low- and Middle-Income Countries: A Systematic Review and Meta-analysis.AIDS and behavior · 2019Pooled it
- Systematic Review of Interventions for Depression for People Living with HIV in Africa.AIDS and behavior · 2018Pooled it
- A Feasibility Study to Develop and Test a Cognitive Behavioral Stress Management Mobile Health Application for HIV-Related Fatigue.Journal of pain and symptom management · 2020Trial
- Predictors of depression recovery in HIV-infected individuals managed through measurement-based care in infectious disease clinics.Journal of affective disorders · 2016Trial
- A Peer-Led HIV Medication Adherence Intervention Targeting Adults Linked to Medical Care but without a Suppressed Viral Load.Journal of the International Association of Providers of AIDS CareTrial
- Virologic re-suppression and the associated factors among children aged 1-9 years on Antiretroviral Therapy in The Aids Support Organization Soroti Region, Uganda: a retrospective cohort analysis.African health sciences · 2024Article
- Depression: an individual-level early warning indicator of virologic failure in HIV patients in South Africa.Public health action · 2024Article
- Psychological and Emotional Impact of COVID-19 Pandemic on People Living with Chronic Disease: HIV and Cancer.AIDS and behavior · 2022Article
- HIV virological non-suppression is highly prevalent among 18- to 24-year-old youths on antiretroviral therapy at the Kenyan coast.BMC infectious diseases · 2022Article
- Article
- A Critical Review of Symptom Management Nursing Science on HIV-Related Fatigue and Sleep Disturbance.International journal of environmental research and public health · 2021Review
- Article
- Urgent need to improve programmatic management of patients with HIV failing first-line antiretroviral therapy.Public health action · 2020Article
- The burden of anxiety among people living with HIV during the COVID-19 pandemic in Pune, India.BMC public health · 2020Article
- Incidence and predictors of virological failure among adult HIV patients on first-line antiretroviral therapy in Amhara regional referral hospitals; Ethiopia: a retrospective follow-up study.BMC infectious diseases · 2020Article
- Identifying mediating variables with graphical models: an application to the study of causal pathways in people living with HIV.Journal of applied statistics · 2020Article
- The Impacts of Residential Location on the Risk of HIV Virologic Failure Among ART Users in Durban, South Africa.AIDS and behavior · 2019Article
- Schistosomiasis and HIV-1 viral load in HIV-infected outpatients with immunological failure in Tanzania: a case-control study.BMC infectious diseases · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 6 institutions in 2 countries.
Funding
Abstract
We sought to develop individual-level Early Warning Indicators (EWI) of virologic failure (VF) for clinicians to use during routine care complementing WHO population-level EWI. A case-control study was conducted at a Durban clinic. Patients after ≥ 5 months of first-line antiretroviral therapy (ART) were defined as cases if they had VF [HIV-1 viral load (VL)>1000 copies/mL] and controls (2:1) if they had VL ≤ 1000 copies/mL. Pharmacy refills and pill counts were used as adherence measures. Participants responded to a questionnaire including validated psychosocial and symptom scales. Data were also collected from the medical record. Multivariable logistic regression models of VF included factors associated with VF (p<0.05) in univariable analyses. We enrolled 158 cases and 300 controls. In the final multivariable model, male gender, not having an active religious faith, practicing unsafe sex, having a family member with HIV, not being pleased with the clinic experience, symptoms of depression, fatigue, or rash, low CD4 counts, family recommending HIV care, and using a TV/radio as ART reminders (compared to mobile phones) were associated with VF independent of adherence measures. In this setting, we identified several key individual-level EWI associated with VF including novel psychosocial factors independent of adherence measures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.