Evidence map›Paper›PMID 24319678›Full record

ArticleBioMed research international2013

Mesenchymal stem cell-like cells derived from mouse induced pluripotent stem cells ameliorate diabetic polyneuropathy in mice.

Tatsuhito Himeno, Hideki Kamiya, Keiko Naruse, Zhao Cheng, Sachiko Ito, Masaki Kondo, Tetsuji Okawa, Atsushi Fujiya, Jiro Kato, Hirohiko Suzuki and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. iScience · 2022
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Production of Mesenchymal Stem Cells Through Stem Cell Reprogramming.International journal of molecular sciences · 2019
    Review
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  16. Article
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  19. Review
  20. Diabetes and stem cell function.BioMed research international · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Tatsuhito HimenoDepartment of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Japan ; Department of Immunology, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Japan.
Hideki Kamiya
Keiko Naruse
Zhao Cheng
Sachiko Ito
Masaki Kondo
Tetsuji Okawa
Atsushi Fujiya
Jiro Kato
Hirohiko Suzuki
Tetsutaro Kito
Yoji Hamada
Yutaka Oiso
Kenichi Isobe
Jiro Nakamura
Nagoya University · JPAichi Medical University · JPAichi Gakuin University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough pathological involvements of diabetic polyneuropathy (DPN) have been reported, no dependable treatment of DPN has been achieved. Recent studies have shown that mesenchymal stem cells (MSCs) ameliorate DPN. Here we demonstrate a differentiation of induced pluripotent stem cells (iPSCs) into MSC-like cells and investigate the therapeutic potential of the MSC-like cell transplantation on DPN. RESEARCH DESIGN AND

methodsFor induction into MSC-like cells, GFP-expressing iPSCs were cultured with retinoic acid, followed by adherent culture for 4 months. The MSC-like cells, characterized with flow cytometry and RT-PCR analyses, were transplanted into muscles of streptozotocin-diabetic mice. Three weeks after the transplantation, neurophysiological functions were evaluated.

resultsThe MSC-like cells expressed MSC markers and angiogenic/neurotrophic factors. The transplanted cells resided in hindlimb muscles and peripheral nerves, and some transplanted cells expressed S100 β in the nerves. Impairments of current perception thresholds, nerve conduction velocities, and plantar skin blood flow in the diabetic mice were ameliorated in limbs with the transplanted cells. The capillary number-to-muscle fiber ratios were increased in transplanted hindlimbs of diabetic mice.

conclusionsThese results suggest that MSC-like cell transplantation might have therapeutic effects on DPN through secreting angiogenic/neurotrophic factors and differentiation to Schwann cell-like cells.

Indexed as

Mesenchymal Stem Cell TransplantationAngiogenesis Inducing AgentsAnimalsbeta-GalactosidaseBiomarkersBlood GlucoseBody WeightCapillariesCell DifferentiationCellular SenescenceCyclin-Dependent Kinase Inhibitor p16Diabetic NeuropathiesExtremitiesGreen Fluorescent ProteinsInduced Pluripotent Stem CellsMaleAngiogenesis Inducing Agentsbeta-GalactosidaseBiomarkersBlood GlucoseCdkn2a protein, mouseCyclin-Dependent Kinase Inhibitor p16Green Fluorescent ProteinsNerve Growth Factors

Identifiers

PMID24319678
PMCPMC3844199
OpenAlexW2140229326

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.