ArticleNeuroImage. Clinical2014
Pathomechanisms and compensatory efforts related to Parkinsonian speech.
Article in NeuroImage. Clinical, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
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Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 93 citations in OpenAlex.
- Neural correlates of emotional prosody in Parkinson's disease: A systematic review.Cognitive, affective & behavioral neuroscience · 2026Pooled it
- Cerebellar Contribution to Motor and Non-motor Functions in Parkinson's Disease: A Meta-Analysis of fMRI Findings.Frontiers in neurology · 2020Pooled it
- Comparing face-to-face and online LSVT®LOUD speech training using LSVT®Coach in patients with Parkinson's disease: a pilot randomised controlled trial.BMC neurology · 2025Trial
- Oxytocinergic modulation of speech production-a double-blind placebo-controlled fMRI study.Social cognitive and affective neuroscience · 2023Trial
- Immediate and long-term effects of speech treatment targets and intensive dosage on Parkinson's disease dysphonia and the speech motor network: Randomized controlled trial.Human brain mapping · 2022Trial
- Speech treatment in Parkinson's disease: Randomized controlled trial (RCT).Movement disorders : official journal of the Movement Disorder Society · 2018Trial
- Striatal network dysfunction underlying speech impairment in early Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Altered Inter-Network Functional Integration Underlies Speech Impairment in Parkinson's Disease: A Resting-State fMRI Analysis.Brain and behavior · 2026Article
- Speech Impairment in Early Parkinson's Disease Is Associated with Nigrostriatal Dopaminergic Dysfunction.Journal of clinical medicine · 2026Article
- Applications of Artificial Intelligence in Neurological Voice Disorders.World journal of otorhinolaryngology - head and neck surgery · 2025Review
- Acoustic assessment in mandarin-speaking Parkinson's disease patients and disease progression monitoring and brain impairment within the speech subsystem.NPJ Parkinson's disease · 2024Review
- Levodopa may modulate specific speech impairment in Parkinson's disease: an fMRI study.Journal of neural transmission (Vienna, Austria : 1996) · 2024Article
- A neurocomputational view of the effects of Parkinson's disease on speech production.Frontiers in human neuroscience · 2024Article
- Aberrant neurophysiological signaling associated with speech impairments in Parkinson's disease.NPJ Parkinson's disease · 2023Article
- Premotor cortex is hypoactive during sustained vowel production in individuals with Parkinson's disease and hypophonia.Frontiers in human neuroscience · 2023Article
- Multi-Modal Rehabilitation Therapy in Parkinson's Disease and Related Disorders.Annals of Indian Academy of Neurology · 2023Article
- Continuous theta burst stimulation over left supplementary motor area facilitates auditory-vocal integration in individuals with Parkinson's disease.Frontiers in aging neuroscience · 2022Article
- Characterization of Mild and Moderate Dysarthria in Parkinson's Disease: Behavioral Measures and Neural Correlates.Frontiers in aging neuroscience · 2022Article
- Subthalamic stimulation breaks the balance between distal and axial signs in Parkinson's disease.Scientific reports · 2021Article
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Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Voice and speech in Parkinson's disease (PD) patients are classically affected by a hypophonia, dysprosody, and dysarthria. The underlying pathomechanisms of these disabling symptoms are not well understood. To identify functional anomalies related to pathophysiology and compensation we compared speech-related brain activity and effective connectivity in early PD patients who did not yet develop voice or speech symptoms and matched controls. During fMRI 20 PD patients ON and OFF levodopa and 20 control participants read 75 sentences covertly, overtly with neutral, or with happy intonation. A cue-target reading paradigm allowed for dissociating task preparation from execution. We found pathologically reduced striato-prefrontal preparatory effective connectivity in early PD patients associated with subcortical (OFF state) or cortical (ON state) compensatory networks. While speaking, PD patients showed signs of diminished monitoring of external auditory feedback. During generation of affective prosody, a reduced functional coupling between the ventral and dorsal striatum was observed. Our results suggest three pathomechanisms affecting speech in PD: While diminished energization on the basis of striato-prefrontal hypo-connectivity together with dysfunctional self-monitoring mechanisms could underlie hypophonia, dysarthria may result from fading speech motor representations given that they are not sufficiently well updated by external auditory feedback. A pathological interplay between the limbic and sensorimotor striatum could interfere with affective modulation of speech routines, which affects emotional prosody generation. However, early PD patients show compensatory mechanisms that could help improve future speech therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.