ArticleSoft matter2013
PAMAM Dendrimers as Quantized Building Blocks for Novel Nanostructures.
Article in Soft matter, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Synthesis of Biocompatible and Biodegradable Polyamidoamines Microgels via a Simple and Reliable Statistical Approach.Materials (Basel, Switzerland) · 2022Article
- Review
- Article
- Chemical characterization (LC-MS-ESI), cytotoxic activity and intracellular localization of PAMAM G4 in leukemia cells.Scientific reports · 2021Article
- Synthesis, Internalization and Visualization ofMolecules (Basel, Switzerland) · 2020Article
- Mixed-Generation PAMAM G3-G0 Megamer as a Drug Delivery System for Nimesulide: Antitumor Activity of the Conjugate Against Human Squamous Carcinoma and Glioblastoma Cells.International journal of molecular sciences · 2019Article
- Polymerization of a divalent/tetravalent metal-storing atom-mimicking dendrimer.Science advances · 2016Article
- Generation 3 PAMAM dendrimer TAMRA conjugates containing precise dye/dendrimer ratios.Materials today (Kidlington, England) · 2015Article
- Recent advances in click chemistry applied to dendrimer synthesis.Molecules (Basel, Switzerland) · 2015Review
- Poly(amidoamine) dendrimer-methotrexate conjugates: the mechanism of interaction with folate binding protein.Molecular pharmaceutics · 2014Article
- Multivalent polymers for drug delivery and imaging: the challenges of conjugation.Biomacromolecules · 2014Review
- Diffusion NMR study of generation-five PAMAM dendrimer materials.The journal of physical chemistry. B · 2014Article
- Avidity mechanism of dendrimer-folic acid conjugates.Molecular pharmaceutics · 2014Article
- Isolation and characterization of precise dye/dendrimer ratios.Chemistry (Weinheim an der Bergstrasse, Germany) · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The desire to synthesize soft supramolecular structures with size scales similar to biological systems has led to work in assembly of polymeric nanomaterials. Recent advances in the isolation of generationally homogenous poly(amidoamine) (PAMAM) dendrimer enables their use as quantized building blocks. Here, we report their assembly into precise nanoclusters. In this work, click-functional ligands are stochastically conjugated to monomeric generation 5 PAMAM dendrimer and separated via reverse-phase HPLC to isolate dendrimers with precise numbers of click ligands per dendrimer particle. The click-ligand/dendrimer conjugates are then employed as modular building blocks for the synthesis of defined nanostructures. Complimentary click chemistry employing dendrimers with 1, 2, 3, or 4 ring-strained cyclooctyne ligands and dendrimers with 1 azide ligand were utilized to prepare megamer structures containing 2 to 5 ~30,000 kDa monomer units as characterized by mass spectrometry, size exclusion chromatography, and reverse-phase liquid chromatography. The resulting structures are flexible with masses ranging from 60,000 to 150,000 kDa, and are soluble in water, methanol, and dimethylsulfoxide.
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Registered trials
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