ArticleMolecular & cellular proteomics : MCP2014
Global analysis of cdc14 dephosphorylation sites reveals essential regulatory role in mitosis and cytokinesis.
Article in Molecular & cellular proteomics : MCP, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- FgMob1 is involved in mitotic exit and regulates the development, abiotic stress response, and pathogenicity ofFrontiers in plant science · 2026Article
- Article
- Analog-sensitive Cdk1 as a tool to study mitotic exit: protein phosphatase 1 is required downstream from Cdk1 inactivation in budding yeast.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2023Article
- Exit from Mitosis in Budding Yeast: Protein Phosphatase 1 is Required Downstream from Cdk1 Inactivation.Research square · 2023Article
- GScience (New York, N.Y.) · 2021Article
- The regulation of Net1/Cdc14 by the Hog1 MAPK upon osmostress unravels a new mechanism regulating mitosis.Cell cycle (Georgetown, Tex.) · 2020Review
- Hog1 activation delays mitotic exit via phosphorylation of Net1.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The Multiple Roles of the Cdc14 Phosphatase in Cell Cycle Control.International journal of molecular sciences · 2020Review
- Review
- Cyclin-Specific Docking Mechanisms Reveal the Complexity of M-CDK Function in the Cell Cycle.Molecular cell · 2019Article
- Proteins that physically interact with the phosphatase Cdc14 in Candida albicans have diverse roles in the cell cycle.Scientific reports · 2019Article
- Protein phosphatases of Saccharomyces cerevisiae.Current genetics · 2019Review
- SILAC-based phosphoproteomics reveals new PP2A-Cdc55-regulated processes in budding yeast.GigaScience · 2018Article
- TheFrontiers in cellular and infection microbiology · 2018Article
- Telomere shortening triggers a feedback loop to enhance end protection.Nucleic acids research · 2017Article
- Cdc15 Phosphorylates the C-terminal Domain of RNA Polymerase II for Transcription during Mitosis.The Journal of biological chemistry · 2017Article
- APC/CScientific reports · 2016Article
- Synthetic physical interactions map kinetochore regulators and regions sensitive to constitutive Cdc14 localization.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- A high-sensitivity phospho-switch triggered by Cdk1 governs chromosome morphogenesis during cell division.Genes & development · 2015Article
- Identification of Cdk targets that control cytokinesis.The EMBO journal · 2015Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Degradation of the M phase cyclins triggers the exit from M phase. Cdc14 is the major phosphatase required for the exit from the M phase. One of the functions of Cdc14 is to dephosphorylate and activate the Cdh1/APC/C complex, resulting in the degradation of the M phase cyclins. However, other crucial targets of Cdc14 for mitosis and cytokinesis remain to be elucidated. Here we systematically analyzed the positions of dephosphorylation sites for Cdc14 in the budding yeast Saccharomyces cerevisiae. Quantitative mass spectrometry identified a total of 835 dephosphorylation sites on 455 potential Cdc14 substrates in vivo. We validated two events, and through functional studies we discovered that Cdc14-mediated dephosphorylation of Smc4 and Bud3 is essential for proper mitosis and cytokinesis, respectively. These results provide insight into the Cdc14-mediated pathways for exiting the M phase.
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