ReviewCurrent topics in behavioral neurosciences2014
Neurogenetics of aggressive behavior: studies in rodents.
Review in Current topics in behavioral neurosciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
97 citing papers in PubMed, 1 synthesis or guideline pooled it, 217 citations in OpenAlex.
- Effectiveness of deep brain stimulation on refractory aggression in pediatric patients with autism and severe intellectual disability: meta-analytic review.BMC pediatrics · 2024Pooled it
- Dopamine modulation of aggression.Psychopharmacology · 2026Review
- Repeated Stress Escalates Aggression and Activity in Fronto-Limbic Regions in Cntnap2Genes, brain, and behavior · 2026Article
- Factors Modulating the Effects of Juvenile Social Isolation on Adult Social Behavior in Rodents.Developmental psychobiology · 2026Review
- Effects of Chronic 100 mg/kg Cannabidiol Treatment in Male Double TransgenicPharmaceuticals (Basel, Switzerland) · 2026Article
- The Highly Selective 5-HTCells · 2026Article
- Development of an automated approach for investigating social learning in mice.Frontiers in behavioral neuroscience · 2026Article
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- Impaired vasopressin neuromodulation of the lateral septum leads to social behavior deficits in Shank3BNature communications · 2025Article
- Maternal dietary folate imbalance alters cerebellar astrocyte morphology and density in offspring.IBRO neuroscience reports · 2025Article
- Developmental lead exposure and aggression in male rats: Influences of maternal care and environmental enrichment.Toxicology reports · 2025Article
- Dynamic changes of serotonin transporter expression in the prefrontal cortex evoked by aggressive social interactions.Neurobiology of stress · 2025Article
- How can ethology inform the neuroscience of fear, aggression and dominance?Nature reviews. Neuroscience · 2024Review
- Stress, hypothalamic-pituitary-adrenal axis, hypothalamic-pituitary-gonadal axis, and aggression.Metabolic brain disease · 2024Review
- Aggression Unleashed: Neural Circuits from Scent to Brain.Brain sciences · 2024Review
- Addressing Combative Behaviour in Spanish Bulls by Measuring Hormonal Indicators.Veterinary sciences · 2024Article
- Exploring the influence of stress on aggressive behavior and sexual function: Role of neuromodulator pathways and epigenetics.Heliyon · 2024Review
- Solitude and serotonin: juvenile isolation alters the covariation between social behavior and cFos expression by serotonergic neurons.Frontiers in neuroscience · 2024Article
- Central amygdala is related to the reduction of aggressive behavior by monosodium glutamate ingestion during the period of development in an ADHD model rat.Frontiers in nutrition · 2024Article
- Article
37 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Aggressive behavior is observed in many animal species, such as insects, fish, lizards, frogs, and most mammals including humans. This wide range of conservation underscores the importance of aggressive behavior in the animals' survival and fitness, and the likely heritability of this behavior. Although typical patterns of aggressive behavior differ between species, there are several concordances in the neurobiology of aggression among rodents, primates, and humans. Studies with rodent models may eventually help us to understand the neurogenetic architecture of aggression in humans. However, it is important to recognize the difference between the ecological and ethological significance of aggressive behavior (species-typical aggression) and maladaptive violence (escalated aggression) when applying the findings of aggression research using animal models to human or veterinary medicine. Well-studied rodent models for aggressive behavior in the laboratory setting include the mouse (Mus musculus), rat (Rattus norvegicus), hamster (Mesocricetus auratus), and prairie vole (Microtus ochrogaster). The neural circuits of rodent aggression have been gradually elucidated by several techniques, e.g., immunohistochemistry of immediate-early gene (c-Fos) expression, intracranial drug microinjection, in vivo microdialysis, and optogenetics techniques. Also, evidence accumulated from the analysis of gene-knockout mice shows the involvement of several genes in aggression. Here, we review the brain circuits that have been implicated in aggression, such as the hypothalamus, prefrontal cortex (PFC), dorsal raphe nucleus (DRN), nucleus accumbens (NAc), and olfactory system. We then discuss the roles of glutamate and γ-aminobutyric acid (GABA), excitatory and inhibitory amino acids in the brain, as well as their receptors, in controlling aggressive behavior, focusing mainly on recent findings. At the end of this chapter, we discuss how genes can be identified that underlie individual differences in aggression, using the so-called forward genetics approach.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.