ArticleG3 (Bethesda, Md.)2014
Genome-wide gene expression effects of sex chromosome imprinting in Drosophila.
Article in G3 (Bethesda, Md.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- The impact of P-element-induced hybrid dysgenesis on the male germline in Drosophila simulans.Genetics · 2026Article
- Fitness consequences of sex chromosome aneuploidy in Drosophila melanogaster.PLoS genetics · 2025Article
- The Evolutionary History of Drosophila simulans Y Chromosomes Reveals Molecular Signatures of Resistance to Sex Ratio Meiotic Drive.Molecular biology and evolution · 2023Article
- Genetic control of a sex-specific piRNA program.Current biology : CB · 2023Article
- Effects of antibiotics on theFrontiers in bioengineering and biotechnology · 2023Article
- Sex-specific plasticity across generations II: Grandpaternal effects are lineage specific and sex specific.The Journal of animal ecology · 2020Article
- The Drosophila Y Chromosome Affects Heterochromatin Integrity Genome-Wide.Molecular biology and evolution · 2020Article
- Preferential Mapping of Sex-Biased Differentially-Expressed Genes of Larvae to the Sex-Determining Region of Flathead Grey Mullet (Frontiers in genetics · 2020Article
- Ancestral diet transgenerationally influences offspring in a parent-of-origin and sex-specific manner.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Heritability estimation and differential analysis of count data with generalized linear mixed models in genomic sequencing studies.Bioinformatics (Oxford, England) · 2019Article
- Review
- Sex-specific adaptation and genomic responses to Y chromosome presence in female reproductive and neural tissues.Proceedings. Biological sciences · 2017Article
- Differential expression analysis for RNAseq using Poisson mixed models.Nucleic acids research · 2017Article
- Conservation of Repeats at the Mammalian KCNQ1OT1-CDKN1C Region Suggests a Role in Genomic Imprinting.Evolutionary bioinformatics online · 2017Article
- Article
- The genetics of pubertal timing in the general population: recent advances and evidence for sex-specificity.Current opinion in endocrinology, diabetes, and obesity · 2016Review
- Endogenously imprinted genes in Drosophila melanogaster.Molecular genetics and genomics : MGG · 2014Article
- How do y-chromosomes modulate genome-wide epigenetic States: genome folding, chromatin sinks, and gene expression.Journal of genomics · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Imprinting is well-documented in both plant and animal species. In Drosophila, the Y chromosome is differently modified when transmitted through the male and female germlines. Here, we report genome-wide gene expression effects resulting from reversed parent-of-origin of the X and Y chromosomes. We found that hundreds of genes are differentially expressed between adult male Drosophila melanogaster that differ in the maternal and paternal origin of the sex chromosomes. Many of the differentially regulated genes are expressed specifically in testis and midgut cells, suggesting that sex chromosome imprinting might globally impact gene expression in these tissues. In contrast, we observed much fewer Y-linked parent-of-origin effects on genome-wide gene expression in females carrying a Y chromosome, indicating that gene expression in females is less sensitive to sex chromosome parent-of-origin. Genes whose expression differs between females inheriting a maternal or paternal Y chromosome also show sex chromosome parent-of-origin effects in males, but the direction of the effects on gene expression (overexpression or underexpression) differ between the sexes. We suggest that passage of sex chromosome chromatin through male meiosis may be required for wild-type function in F1 progeny, whereas disruption of Y-chromosome function through passage in the female germline likely arises because the chromosome is not adapted to the female germline environment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.